Academic Journal
Formalin Evokes Calcium Transients from the Endoplasmatic Reticulum
| العنوان: | Formalin Evokes Calcium Transients from the Endoplasmatic Reticulum |
|---|---|
| المؤلفون: | Fischer, Michael J. M., Soller, Kailey J., Sauer, Susanne K., Kalucka, Joanna, Veglia, Gianluigi, Reeh, Peter W. |
| سنة النشر: | 2015 |
| المجموعة: | OPUS FAU - Online publication system of Friedrich-Alexander-Universität Erlangen-Nürnberg |
| مصطلحات موضوعية: | ddc:610 |
| الوصف: | The formalin test is the most widely used behavioral screening test for analgesic compounds. The cellular mechanism of action of formaldehyde, inducing a typically biphasic pain-related behavior in rodents is addressed in this study. The chemoreceptor channel TRPA1 was suggested as primary transducer, but the high concentrations used in the formalin test elicit a similar response in TRPA1 wildtype and knockout animals. Here we show that formaldehyde evokes a dose-dependent calcium release from intracellular stores in mouse sensory neurons and primary keratinocytes as well as in non-neuronal cell lines, and independent of TRPA1. The source of calcium is the endoplasmatic reticulum and inhibition of the sarco/endoplasmic reticulum calcium-ATPase has a major contribution. This TRPA1-independent mechanism may underlie formaldehyde-induced pan-neuronal excitation and subsequent inflammation. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://opus4.kobv.de/opus4-fau/frontdoor/index/index/docId/6164; urn:nbn:de:bvb:29-opus4-61644; https://nbn-resolving.org/urn:nbn:de:bvb:29-opus4-61644; https://opus4.kobv.de/opus4-fau/files/6164/fischer_formalin.pdf |
| الاتاحة: | https://opus4.kobv.de/opus4-fau/frontdoor/index/index/docId/6164 https://nbn-resolving.org/urn:nbn:de:bvb:29-opus4-61644 https://opus4.kobv.de/opus4-fau/files/6164/fischer_formalin.pdf |
| Rights: | https://creativecommons.org/licenses/by/3.0/de/deed.de ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.19375CC |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |