Academic Journal
Defining the End Point of Drug Therapy in Tuberculosis of Spine: Analysis of 76 Cases in a Tertiary Care Center
| العنوان: | Defining the End Point of Drug Therapy in Tuberculosis of Spine: Analysis of 76 Cases in a Tertiary Care Center |
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| المؤلفون: | Amresh Kumar, Kumar Rahul Raushan |
| المصدر: | International Journal of Pharmaceutical and Clinical Research, 16(6), 2495-2498, (2024-06-30) |
| بيانات النشر: | International Journal of Pharmaceutical and Clinical Research |
| سنة النشر: | 2024 |
| المجموعة: | Zenodo |
| مصطلحات موضوعية: | Tuberculosis, Spine, Treatment Duration, Clinical Improvement, Radiological Healing |
| الوصف: | Introduction: Tuberculosis of the spine, or spinal TB, requires prolonged treatment, with unclear guidelines on the optimal duration. This study addresses these uncertainties by evaluating the treatment endpoints for spinal TB. Methodology: A retrospective observational study was conducted on 76 spinal TB patients at Jawahar Lal Nehru Medical College & Hospital from October 2020 to August 2023. The analysis focused on clinical and radiological outcomes to determine effective cessation points for therapy. Results: The majority (60.5%) of patients completed their treatment between 6 and 12 months, achieving clinical improvement (92.1%) and radiological healing (89.5%). The relapse rate was low at 6.6%, with adverse events such as hepatotoxicity (11.8%), renal impairment (5.3%), and peripheral neuropathy (9.2%) being the most significant. Conclusion: The findings suggest that a 6–12-month treatment regimen is generally adequate for spinal TB, balancing efficacy and safety. The low relapse rate supports the effectiveness of this treatment window. Recommendation: Future studies should focus on refining treatment durations and developing personalized approaches based on patient-specific responses and potential complications. ; Introduction: Tuberculosis of the spine, or spinal TB, requires prolonged treatment, with unclear guidelines on the optimal duration. This study addresses these uncertainties by evaluating the treatment endpoints for spinal TB. Methodology: A retrospective observational study was conducted on 76 spinal TB patients at Jawahar Lal Nehru Medical College & Hospital from October 2020 to August 2023. The analysis focused on clinical and radiological outcomes to determine effective cessation points for therapy. Results: The majority (60.5%) of patients completed their treatment between 6 and 12 months, achieving clinical improvement (92.1%) and radiological healing (89.5%). The relapse rate was low at 6.6%, with adverse events such as hepatotoxicity (11.8%), renal impairment (5.3%), and ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://doi.org/10.5281/zenodo.13851752; https://doi.org/10.5281/zenodo.13851753; oai:zenodo.org:13851753; https://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue6,Article470.pdf |
| DOI: | 10.5281/zenodo.13851753 |
| الاتاحة: | https://doi.org/10.5281/zenodo.13851753 https://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue6,Article470.pdf |
| Rights: | info:eu-repo/semantics/openAccess ; Creative Commons Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0/legalcode |
| رقم الانضمام: | edsbas.190A4CCB |
| قاعدة البيانات: | BASE |
| DOI: | 10.5281/zenodo.13851753 |
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