Academic Journal
The origin, progress, and application of cell‐based cardiac regeneration therapy
| العنوان: | The origin, progress, and application of cell‐based cardiac regeneration therapy |
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| المؤلفون: | Zhuo, Danping, Lei, Ienglam, Li, Wenjun, Liu, Li, Li, Lan, Ni, Jingyu, Liu, Zhihao, Fan, Guanwei |
| المساهمون: | National Natural Science Foundation of China |
| المصدر: | Journal of Cellular Physiology ; volume 238, issue 8, page 1732-1755 ; ISSN 0021-9541 1097-4652 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2023 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Cardiovascular disease (CVD) has become a severe threat to human health, with morbidity and mortality increasing yearly and gradually becoming younger. When the disease progresses to the middle and late stages, the loss of a large number of cardiomyocytes is irreparable to the body itself, and clinical drug therapy and mechanical support therapy cannot reverse the development of the disease. To explore the source of regenerated myocardium in model animals with the ability of heart regeneration through lineage tracing and other methods, and develop a new alternative therapy for CVDs, namely cell therapy. It directly compensates for cardiomyocyte proliferation through adult stem cell differentiation or cell reprogramming, which indirectly promotes cardiomyocyte proliferation through non‐cardiomyocyte paracrine, to play a role in heart repair and regeneration. This review comprehensively summarizes the origin of newly generated cardiomyocytes, the research progress of cardiac regeneration based on cell therapy, the opportunity and development of cardiac regeneration in the context of bioengineering, and the clinical application of cell therapy in ischemic diseases. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/jcp.31060 |
| الاتاحة: | http://dx.doi.org/10.1002/jcp.31060 https://onlinelibrary.wiley.com/doi/pdf/10.1002/jcp.31060 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.18AC51 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/jcp.31060 |
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