Academic Journal
Bone morphogenetic protein-7 attenuates pancreatic damage under diabetic conditions and prevents progression to diabetic nephropathy via inhibition of ferroptosis
| العنوان: | Bone morphogenetic protein-7 attenuates pancreatic damage under diabetic conditions and prevents progression to diabetic nephropathy via inhibition of ferroptosis |
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| المساهمون: | Sang Hyun Song, Dawool Han, Kyeonghui Park, Jo Eun Um, Seonghun Kim, Minhee Ku, Jaemoon Yang, Tae-Hyun Yoo, Jong In Yook, Nam Hee Kim, Hyun Sil Kim, Ku, Min Hee |
| بيانات النشر: | Frontiers Research |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Animals, Diabetes Mellitus, Experimental* / complications, Experimental* / metabolism, Diabetic Nephropathies* / genetics, Diabetic Nephropathies* / metabolism, Ferroptosis, Mice, Pancreas / metabolism, Rats, Transforming Growth Factor beta / metabolism, Bmp12, TGF-β, diabetic nephropathy, ferroptosis, fibrosis |
| الوصف: | Background: Approximately 30% of diabetic patients develop diabetic nephropathy, a representative microvascular complication. Although the etiological mechanism has not yet been fully elucidated, renal tubular damage by hyperglycemia-induced expression of transforming growth factor-β (TGF-β) is known to be involved. Recently, a new type of cell death by iron metabolism called ferroptosis was reported to be involved in kidney damage in animal models of diabetic nephropathy, which could be induced by TGF-β. Bone morphogenetic protein-7 (BMP7) is a well-known antagonist of TGF-β inhibiting TGF-β-induced fibrosis in many organs. Further, BMP7 has been reported to play a role in the regeneration of pancreatic beta cells in diabetic animal models. Methods: We used protein transduction domain (PTD)-fused BMP7 in micelles (mPTD-BMP7) for long-lasting in vivo effects and effective in vitro transduction and secretion. Results: mPTD-BMP7 successfully accelerated the regeneration of diabetic pancreas and impeded progression to diabetic nephropathy. With the administration of mPTD-BMP7, clinical parameters and representative markers of pancreatic damage were alleviated in a mouse model of streptozotocin-induced diabetes. It not only inhibited the downstream genes of TGF-β but also attenuated ferroptosis in the kidney of the diabetic mouse and TGF-β-stimulated rat kidney tubular cells. Conclusion: BMP7 impedes the progression of diabetic nephropathy by inhibiting the canonical TGF-β pathway, attenuating ferroptosis, and helping regenerate diabetic pancreas. Copyright © 2028 Song, Han, Park, Um, Kim, Ku, Yang, Yoo, Yook, Kim and Kim. ; open |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1664-2392 |
| Relation: | FRONTIERS IN ENDOCRINOLOGY; J03412; OAK-2023-01970; OAK-2023-01971; OAK-2023-01972; OAK-2023-01973; OAK-2023-01974; OAK-2023-01975; https://ir.ymlib.yonsei.ac.kr/handle/22282913/195522; T202303495; FRONTIERS IN ENDOCRINOLOGY, Vol.14 : 1172199, 2023-05 |
| DOI: | 10.3389/fendo.2023.1172199 |
| الاتاحة: | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195522 https://doi.org/10.3389/fendo.2023.1172199 |
| Rights: | CC BY-NC-ND 2.0 KR |
| رقم الانضمام: | edsbas.18A87E2E |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16642392 |
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| DOI: | 10.3389/fendo.2023.1172199 |