التفاصيل البيبلوغرافية
| العنوان: |
Outcomes after Allogeneic Hematopoietic Cell Transplant in patients diagnosed with Blast Phase of Myeloproliferative Neoplasms: a retrospective study from the Chronic Malignancies Working Party of the EBMT. |
| المؤلفون: |
Ortí, Guillermo, Gras, Luuk, Zinger, Nienke, Finazzi, Maria Chiara, Sockel, Katja, Robin, Marie, Forcade, Edouard, Avenoso, Daniele, Kröger, Nicolaus, Finke, Jürgen, Radujkovic, Aleksandar, Hunault-Berger, Mathilde, Schroyens, Wilfried, Zuckerman, Tsila, Bourhis, Jean-Henri, Chalandon, Yves, Bloor, Adrian, Schots, Rik, De Wreede, Liesbeth C., Drozd-Sokolowska, Joana, Raj, Kavita, Polverelli, Nicola, Czerw, Tomasz, Hernandez-Boluda, Juan Carlos, Mclornan, Donal P., Yakoub-Agha, Ibrahim |
| المساهمون: |
Université de Lille, Inserm, CHU Lille, Vall d'Hebron Institute of Oncology Barcelone VHIO, Universiteit Leiden = Leiden University, Leiden University Medical Center LUMC, Università degli Studi di Milano = University of Milan UNIMI, University Hospital Carl Gustav Carus Dresden, Germany, Hopital Saint-Louis AP-HP AP-HP, CHU Bordeaux, King's College Hospital KCH, University Hospital Hamburg-Eppendorf, University of Freiburg Freiburg, University of Heidelberg, Medical Faculty, Centre Hospitalier Universitaire d'Angers CHU Angers, Antwerp University Hospital Edegem UZA, Institut Gustave Roussy IGR, Geneva University Hospitals and Geneva University, The Christie NHS Foundation Trust Manchester, Royaume-Uni, Universitair Ziekenhuis Brussel = University Hospital of Brussels UZ Brussel, Medical University of Warsaw - Poland, University College London Hospitals NHS Foundation Trust London, UK UCLH, Università degli Studi di Brescia = University of Brescia UniBs, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology MCMCC, Universitat Politècnica de València = Universitad Politecnica de Valencia = Polytechnic University of Valencia UPV, Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286 |
| سنة النشر: |
2024 |
| المجموعة: |
LillOA (Lille Open Archive - Université de Lille) |
| الوصف: |
Allogeneic hematopoietic cell transplant (allo-HCT) provides the only potential route to long-term remission in patients diagnosed with blast phase transformation of myeloproliferative neoplasm (BP-MPN). We report on a large, retrospective European Society for Blood and Marrow Transplantation registry-based study of BP-MPN patients undergoing allo-HCT. BP-MPN patients undergoing first allo-HCT between 2005 and 2019 were included. A total of 663 patients were included. With a median follow-up of 62 months, the estimated 3-year overall survival (OS) was 36% (95% confidence interval [CI], 32–36). Factors associated with lower OS were Karnofsky Performance Score (KPS) <90 (hazard ratio [HR] 1.65, p < .001) and active disease at allo-HCT (HR 1.45, p < .001), whereas patients undergoing allo-HCT more recently associated with a higher OS (HR 0.96, p = .008). In a selected patient's population, the 3-year OS of patients undergoing allo-HCT in complete response (CR) and with a KPS ≥90 was 60%. KPS < 90 (HR 1.4, p = .001) and active disease (HR 1.44, p = .0004) were associated with a lower progression-free survival (PFS). Conversely, most recent allo-HCT associated with a higher PFS (HR 0.96, p = .008). Active disease at allo-HCT (HR 1.34, p = .03) was associated with a higher cumulative incidence of relapse (RI) and allo-HCT in earlier calendar years (HR 0.96, p = .02) associated with a lower RI. Last, KPS < 90 (HR 1.91, p < .001), active disease (HR 1.74, p = .003) and allo-HCT from mismatched related donors were associated with a higher non-relapse mortality (HR 2.66, p = .003). In this large series of BP-MPN patients, about one third were alive at 3 years after transplantation. Patients undergoing allo-HCT in the more recent era, with a KPS ≥90 and in CR at transplant had a better prognosis. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/octet-stream |
| اللغة: |
English |
| Relation: |
American Journal of Hematology; Am J Hematol; http://hdl.handle.net/20.500.12210/100662 |
| الاتاحة: |
https://hdl.handle.net/20.500.12210/100662 |
| رقم الانضمام: |
edsbas.188D907F |
| قاعدة البيانات: |
BASE |