Academic Journal
Body mass index and von Hippel-Lindau gene mutations in clear-cell renal cancer: Results of the Netherlands Cohort Study on diet and cancer.
| العنوان: | Body mass index and von Hippel-Lindau gene mutations in clear-cell renal cancer: Results of the Netherlands Cohort Study on diet and cancer. |
|---|---|
| المؤلفون: | Smits, K.M., Schouten, L.J., Hudak, E., Verhage, B., Dijk, B.A. van, Hulsbergen-van de Kaa, C.A., Goldbohm, R.A., Oosterwijk, E., Brandt, P.A. van den |
| المصدر: | Annals of Epidemiology, 20, 5, pp. 401-4 |
| سنة النشر: | 2010 |
| المجموعة: | Radboud University: DSpace |
| مصطلحات موضوعية: | NCMLS 6: Genetics and epigenetic pathways of disease, ONCOL 3: Translational research |
| الوصف: | Contains fulltext : 88671.pdf (Publisher’s version ) (Closed access) ; PURPOSE: Body mass index (BMI) is an important risk factor for clear-cell renal cancer (cc-RCC). A common molecular alteration in cc-RCC is loss-of-function of the von Hippel-Lindau (VHL) gene. We evaluated the association between BMI and VHL mutations in cc-RCC by using data from the Netherlands Cohort Study (NLCS), a prospective study, which comprises 120,852 persons. METHODS: After 11.3 years of follow-up, 337 incident RCC cases were identified; 185 cc-RCC cases were included for analyses. RESULTS: A high BMI at baseline was associated with an increased risk of cc-RCC with or without VHL mutations (per 1 kg/m(2): hazard ratio [HR] = 1.09, 95% confidence interval [CI]: 1.02-1.16 and HR = 1.08, 95%CI: 1.01-1.15, respectively). BMI at age 20 was only associated with an increased risk of cc-RCC with VHL mutations (per 1 kg/m(2): HR =1.09, 95% CI: 1.03-1.16). In contrast, BMI gain since age 20 was only associated with an increased risk in VHL wild-type cases (per 1 kg/m(2): HR = 1.10, 95% CI: 1.03-1.19). CONCLUSION: Our findings indicate that BMI may be differently associated with subtypes of RCC based on VHL mutations. ; 01 mei 2010 |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | http://hdl.handle.net/2066/88671 |
| DOI: | 10.1016/j.annepidem.2010.01.010 |
| الاتاحة: | http://hdl.handle.net/2066/88671 https://doi.org/10.1016/j.annepidem.2010.01.010 |
| رقم الانضمام: | edsbas.18790D16 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.annepidem.2010.01.010 |
|---|