Academic Journal
ajcr0000123f
| العنوان: | ajcr0000123f |
|---|---|
| المؤلفون: | Joseph P Garay, Ben H Park, Dwang |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | http://www.ajcr.us/files/ajcr0000123.pdf. |
| سنة النشر: | 2012 |
| المجموعة: | CiteSeerX |
| الوصف: | Breast cancer occurs at a high frequency in women and, given this fact, a primary focus of breast cancer research has been the study of estrogen receptor α (ER) signaling. However, androgens are known to play a role in normal breast physiology and therefore androgen receptor (AR) signaling is becoming increasingly recognized as an important contributor towards breast carcinogenesis. Moreover, the high frequency of AR expression in breast cancer makes it an attractive therapeutic target, but the ability to exploit AR for therapy has been difficult. Here we review the historical use of androgen/anti-androgen therapies in breast cancer, the challenges of accurately modeling nuclear hormone receptor signaling in vitro, and the presence and prognostic significance of AR in breast cancer. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1075.863; http://www.ajcr.us/files/ajcr0000123.pdf |
| الاتاحة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1075.863 http://www.ajcr.us/files/ajcr0000123.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.185DF97B |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |