Academic Journal
BNT162b2 versus mRNA-1273 Third Dose COVID-19 Vaccine in Patients with CKD and Maintenance Dialysis Patients
| العنوان: | BNT162b2 versus mRNA-1273 Third Dose COVID-19 Vaccine in Patients with CKD and Maintenance Dialysis Patients |
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| المؤلفون: | Yau, Kevin, Tam, Paul, Chan, Christopher T., Hu, Queenie, Qi, Freda, Abe, Kento T., Kurtesi, Alexandra, Jiang, Yidi, Estrada-Codecido, Jose, Brown, Tyler, Liu, Lisa, Siwakoti, Aswani, Leis, Jerome A., Levin, Adeera, Oliver, Matthew J., Colwill, Karen, Gingras, Anne-Claude, Hladunewich, Michelle A. |
| المساهمون: | COVID-19 Immunity Task Force, Oreopoulos/Baxter Home Dialysis Grant, Canadian Institutes of Health Research |
| المصدر: | Clinical Journal of the American Society of Nephrology ; volume 19, issue 1, page 85-97 ; ISSN 1555-9041 1555-905X |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health) |
| سنة النشر: | 2023 |
| الوصف: | Background There is a lack of randomized controlled trial data regarding differences in immunogenicity of varying coronavirus disease 2019 (COVID-19) mRNA vaccine regimens in CKD populations. Methods We conducted a randomized controlled trial at three kidney centers in Toronto, Ontario, Canada, evaluating the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody response after third dose vaccination. Participants ( n =273) with CKD not on dialysis or receiving dialysis were randomized 1:1 to third dose 30- µ g BNT162b2 (Pfizer-BioNTech) or 100- µ g mRNA-1273 (Moderna). The primary outcome of this study was SARS-CoV-2 IgG-binding antibodies to the receptor-binding domain (anti-RBD). Spike protein (antispike), nucleocapsid protein, and vaccine reactogenicity were also evaluated. Serology was measured before third dose and 1, 3, and 6 months after third dose. A subset of participants ( n =100) were randomly selected to assess viral pseudovirus neutralization against wild-type D614G, B.1.617.2 (Delta), and B.1.1.529 (Omicron BA.1). Results Among 273 participants randomized, 94% were receiving maintenance dialysis and 59% received BNT162b2 for initial two dose COVID-19 vaccination. Third dose of mRNA-1273 was associated with higher mean anti-RBD levels (1871 binding antibody units [BAU]/ml; 95% confidence interval [CI], 829 to 2988) over a 6-month period in comparison with third dose BNT162b2 (1332 BAU/ml; 95% CI, 367 to 2402) with a difference of 539 BAU/ml (95% CI, 139 to 910; P = 0.009). Neither antispike levels nor neutralizing antibodies to wild-type, Delta, and Omicron BA.1 pseudoviruses were statistically different. COVID-19 infection occurred in 10% of participants: 15 (11%) receiving mRNA-1273 and 11 (8%) receiving BNT162b2. Third dose BNT162b2 was not associated with a significant different risk for COVID-19 in comparison with mRNA-1273 (hazard ratio, 0.78; 95% CI, 0.27 to 2.2; P = 0.63). Conclusions In patients with CKD, third dose COVID-19 mRNA vaccination with mRNA-1273 elicited higher ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.2215/cjn.0000000000000328 |
| DOI: | 10.2215/CJN.0000000000000328 |
| الاتاحة: | http://dx.doi.org/10.2215/cjn.0000000000000328 https://journals.lww.com/10.2215/CJN.0000000000000328 |
| Rights: | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| رقم الانضمام: | edsbas.185C9292 |
| قاعدة البيانات: | BASE |
| DOI: | 10.2215/cjn.0000000000000328 |
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