Academic Journal
BTG1 inactivation drives lymphomagenesis and promotes lymphoma dissemination through activation of BCAR1
| العنوان: | BTG1 inactivation drives lymphomagenesis and promotes lymphoma dissemination through activation of BCAR1 |
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| المؤلفون: | Delage, Lorric, Lambert, Mireille, Bardel, Émilie, Kundlacz, Cindy, Chartoire, Dimitri, Conchon, Axel, Peugnet, Anne-Laure, Gorka, Lucas, Auberger, Patrick, Jacquel, Arnaud, Soussain, Carole, Destaing, Olivier, Delecluse, Henri-Jacques, Delecluse, Susanne, Merabet, Samir, Traverse-Glehen, Alexandra, Salles, Gilles, Bachy, Emmanuel, Billaud, Marc, Ghesquières, Hervé, Genestier, Laurent, Rouault, Jean-Pierre, Sujobert, Pierre |
| المساهمون: | Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre méditerranéen de médecine moléculaire (C3M), Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UniCA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Hospices Civils de Lyon (HCL), Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard Lyon -Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de Génomique Fonctionnelle de Lyon (IGFL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut Curie - Saint Cloud (ICSC), Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire CHU Grenoble (CHUGA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), German Cancer Research Center (DKFZ), Heidelberg, Germany, Memorial Sloane Kettering Cancer Center New York, Département cancer environnement (Centre Léon Bérard - Lyon), Centre Léon Bérard Lyon, Développement Cancer et Thérapies Ciblées Lyon (LabEx DEVweCAN), Centre Hospitalier Lyon Sud CHU - HCL (CHLS) |
| المصدر: | ISSN: 0006-4971. |
| بيانات النشر: | HAL CCSD American Society of Hematology |
| سنة النشر: | 2023 |
| المجموعة: | Université Jean Monnet – Saint-Etienne: HAL |
| مصطلحات موضوعية: | [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Abstract Understanding the functional role of mutated genes in cancer is required to translate the findings of cancer genomics into therapeutic improvement. BTG1 is recurrently mutated in the MCD/C5 subtype of diffuse large B-cell lymphoma (DLBCL), which is associated with extranodal dissemination. Here, we provide evidence that Btg1 knock out accelerates the development of a lethal lymphoproliferative disease driven by Bcl2 overexpression. Furthermore, we show that the scaffolding protein BCAR1 is a BTG1 partner. Moreover, after BTG1 deletion or expression of BTG1 mutations observed in patients with DLBCL, the overactivation of the BCAR1-RAC1 pathway confers increased migration ability in vitro and in vivo. These modifications are targetable with the SRC inhibitor dasatinib, which opens novel therapeutic opportunities in BTG1 mutated DLBCL. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1182/blood.2022016943 |
| الاتاحة: | https://hal.science/hal-04272019 https://doi.org/10.1182/blood.2022016943 |
| رقم الانضمام: | edsbas.18426165 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1182/blood.2022016943 |
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