التفاصيل البيبلوغرافية
| العنوان: |
Direct Comparison of Therapeutic Effects on Diabetic Polyneuropathy between Transplantation of Dental Pulp Stem Cells and Administration of Dental Pulp Stem Cell-Secreted Factors |
| المؤلفون: |
Saki Kanada, Eriko Makino, Nobuhisa Nakamura, Megumi Miyabe, Mizuho Ito, Masaki Hata, Taisuke Yamauchi, Noritaka Sawada, Shun Kondo, Tomokazu Saiki, Tomomi Minato, Ken Miyazawa, Shigemi Goto, Tatsuaki Matsubara, Keiko Naruse |
| المصدر: |
International Journal of Molecular Sciences; Volume 21; Issue 17; Pages: 6064 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2020 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
dental pulp stem cell, diabetic polyneuropathy, secreted factor, transplantation, regenerative medicine |
| جغرافية الموضوع: |
agris |
| الوصف: |
Stem cell transplantation is a potential novel therapy for diabetic polyneuropathy. Dental pulp stem cells (DPSCs) are attractive stem cell sources because DPSCs can be isolated from extracted teeth and cryopreserved while retaining viability. In this study, we directly compared the efficacy of the transplantation of DPSCs and the administration of the secreted factors from DPSCs (DPSC-SFs) on diabetic polyneuropathy. Eight weeks after streptozotocin injection, DPSCs (1.0 × 106 cells/rat) or DPSC-SFs (1.0 mL/rat) were administered into the unilateral hindlimb skeletal muscles of diabetic Sprague–Dawley rats. DPSC transplantation and DPSC-SF administration did not affect blood glucose levels and body weights in the diabetic rats. Both DPSC transplantation and DPSC-SF administration significantly ameliorated sciatic nerve conduction velocity and sciatic nerve blood flow, accompanied by increases in muscle bundle size, vascular density in the skeletal muscles and intraepidermal nerve fiber density in the diabetic rats, while there was no difference between the results for DPSCs and DPSC-SFs. These results suggest that the efficacy of both DPSC transplantation and DPSC-SF administration for diabetic polyneuropathy four weeks after transplantation/administration was mainly due to the multiple secretomes secreted from transplanted DPSCs or directly injected DPSC-SFs in the early phase of transplantation/administration. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Molecular Pathology, Diagnostics, and Therapeutics; https://dx.doi.org/10.3390/ijms21176064 |
| DOI: |
10.3390/ijms21176064 |
| الاتاحة: |
https://doi.org/10.3390/ijms21176064 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.1809E6B6 |
| قاعدة البيانات: |
BASE |