Academic Journal
The clinical application of genetic testing in DILI, are we there yet?
| العنوان: | The clinical application of genetic testing in DILI, are we there yet? |
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| المؤلفون: | Krantz, Matthew S., Marks, Madeline E., Phillips, Elizabeth J. |
| بيانات النشر: | AASLD Publications |
| سنة النشر: | 2024 |
| الوصف: | DILI is a rare adverse reaction to drugs or herbal supplements that often has toxic, metabolic, and immunological contributors. It is the leading cause of acute liver failure in the United States.1 Its incidence is estimated to be 13.9 per 100,000 individuals.2 It has high morbidity and mortality, with 64% of patients with DILI-induced acute liver failure undergoing liver transplantation or dying.3 Most cases of DILI are associated with small molecule drugs; however, 15%–20% of cases are associated with herbal supplements, sometimes known as herbal-induced liver injury.4 Less is known about DILI associated with biologics and large molecules, although immunotherapies such as immune checkpoint inhibitors and other biologics such as TNF receptor antagonists have been implicated.5 Diagnosing DILI and assigning drug causality is often a challenge as patients may be receiving multiple medications concurrently, and presentation may occur significantly after discontinuation of the offending medication. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2046-2484 |
| Relation: | ispartof: Clinical liver disease (Malden, Mass.) issue 1 vol 23; 991005684370207891; https://researchportal.murdoch.edu.au/esploro/outputs/journalArticle/The-clinical-application-of-genetic-testing/991005684370207891; alma:61MUN_INST/bibs/991005684370207891 |
| DOI: | 10.1097/CLD.0000000000000218 |
| الاتاحة: | https://doi.org/10.1097/CLD.0000000000000218 https://researchportal.murdoch.edu.au/esploro/outputs/journalArticle/The-clinical-application-of-genetic-testing/991005684370207891 |
| Rights: | © 2024 American Association for the Study of Liver Diseases. |
| رقم الانضمام: | edsbas.18090998 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20462484 |
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| DOI: | 10.1097/CLD.0000000000000218 |