Academic Journal
Diagnostic performance of a Lattice Boltzmann-based method for CT-based fractional flow reserve
| العنوان: | Diagnostic performance of a Lattice Boltzmann-based method for CT-based fractional flow reserve |
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| المؤلفون: | Giannopoulos, Andreas A, Tang, Anji, Ge, Yin, Cheezum, Michael K, Steigner, Michael L, Fujimoto, Shinichiro, Kumamaru, Kanako K, Chiappino, Dante, Della Latta, Daniele, Berti, Sergio, Chiappino, Sara, Rybicki, Frank J, Melchionna, Simone, Mitsouras, Dimitrios |
| المصدر: | Giannopoulos, Andreas A; Tang, Anji; Ge, Yin; Cheezum, Michael K; Steigner, Michael L; Fujimoto, Shinichiro; Kumamaru, Kanako K; Chiappino, Dante; Della Latta, Daniele; Berti, Sergio; Chiappino, Sara; Rybicki, Frank J; Melchionna, Simone; Mitsouras, Dimitrios (2018). Diagnostic performance of a Lattice Boltzmann-based method for CT-based fractional flow reserve. EuroIntervention, 13(14):1696-1704. |
| بيانات النشر: | Europa Digital and Publishing |
| سنة النشر: | 2018 |
| المجموعة: | University of Zurich (UZH): ZORA (Zurich Open Repository and Archive |
| مصطلحات موضوعية: | Clinic for Nuclear Medicine, 610 Medicine & health |
| الوصف: | AIMS: Fractional flow reserve (FFR) estimated from coronary computed tomography angiography (CT-FFR) offers non-invasive detection of lesion-specific ischaemia. We aimed to develop and validate a fast CT-FFR algorithm utilising the Lattice Boltzmann method for blood flow simulation (LBM CT-FFR). METHODS AND RESULTS: Sixty-four patients with clinically indicated CTA and invasive FFR measurement from three institutions were retrospectively analysed. CT-FFR was performed using an onsite tool interfacing with a commercial Lattice Boltzmann fluid dynamics cloud-based platform. Diagnostic accuracy of LBM CT-FFR ≤0.8 and percent diameter stenosis >50% by CTA to detect invasive FFR ≤0.8 were compared using area under the receiver operating characteristic curve (AUC). Sixty patients successfully underwent LBM CT-FFR analysis; 29 of 73 lesions in 69 vessels had invasive FFR ≤0.8. Total time to perform LBM CT-FFR was 40±10 min. Compared to invasive FFR, LBM CT-FFR had good correlation (r=0.64), small bias (0.009) and good limits of agreement (-0.223 to 0.206). The AUC of LBM CT-FFR (AUC=0.894, 95% confidence interval [CI]: 0.792-0.996) was significantly higher than CTA (AUC=0.685, 95% CI: 0.576-0.794) to detect FFR ≤0.8 (p=0.0021). Per-lesion specificity, sensitivity, and accuracy of LBM CT-FFR were 97.7%, 79.3%, and 90.4%, respectively. CONCLUSIONS: LBM CT-FFR has very good diagnostic accuracy to detect lesion-specific ischaemia (FFR ≤0.8) and can be performed in less than one hour. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1774-024X |
| Relation: | https://www.zora.uzh.ch/152913; info:pmid/28649949; urn:issn:1774-024X |
| الاتاحة: | https://www.zora.uzh.ch/id/eprint/152913/ https://www.zora.uzh.ch/152913 |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.17F3A89B |
| قاعدة البيانات: | BASE |
| تدمد: | 1774024X |
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