Academic Journal

Alliin, An Allium sativum Nutraceutical, Reduces Metaflammation Markers in DIO Mice

التفاصيل البيبلوغرافية
العنوان: Alliin, An Allium sativum Nutraceutical, Reduces Metaflammation Markers in DIO Mice
المؤلفون: Marina A. Sánchez-Sánchez, Adelaida Sara Minia Zepeda-Morales, Lucrecia Carrera-Quintanar, Juan Manuel Viveros-Paredes, Noel Noé Franco-Arroyo, Marisol Godínez-Rubí, Daniel Ortuño-Sahagun, Rocío Ivette López-Roa
المصدر: Nutrients; Volume 12; Issue 3; Pages: 624
بيانات النشر: Multidisciplinary Digital Publishing Institute
سنة النشر: 2020
المجموعة: MDPI Open Access Publishing
مصطلحات موضوعية: obesity, inflammation, cytokines, adipocytokines, s-allyl cysteine sulfoxide, adipose tissue
جغرافية الموضوع: agris
الوصف: Obesity generates a chronic low-grade inflammatory state which promotes oxidative stress and triggers comorbidities. Alliin is the main organosulfur compound in garlic and has been shown to induce a decrease in the expression of proinflammatory cytokines; its systemic effect on metabolic parameters and adipose tissue is not yet known, however. After nine weeks of HFD and with obesity established in C57BL/6 mice, we observed that a daily treatment with alliin for 3.5 weeks (15 mg/kg) did not affect body weight, but significantly improved insulin sensitivity and glucose tolerance, both evaluated through a blood glucose monitoring system. Once alliin treatment was completed, serum, adipose tissue, and organs of interest related to metabolism were removed for further analysis. We observed that alliin significantly decreased the size of adipocytes from epididymal adipose tissue, evaluated via microscopy. A decrease in gene expression and serum protein levels of the adipocytokines leptin and resistin, as well as decreased serum IL-6 concentration, were detected by qRT-PCR and ELISA, respectively. It did not, however, affect mRNA expression of antioxidant enzymes in the liver. Taken altogether, these results indicate that treatment with alliin reduces metaflammation markers in DIO mice and improves some metabolic parameters without affecting others.
نوع الوثيقة: text
وصف الملف: application/pdf
اللغة: English
Relation: Nutritional Immunology; https://dx.doi.org/10.3390/nu12030624
DOI: 10.3390/nu12030624
الاتاحة: https://doi.org/10.3390/nu12030624
Rights: https://creativecommons.org/licenses/by/4.0/
رقم الانضمام: edsbas.17E2D51F
قاعدة البيانات: BASE