Academic Journal
Effects of zinc on the right cardiovascular circuit in long-term hypobaric hypoxia in wistar rats
| العنوان: | Effects of zinc on the right cardiovascular circuit in long-term hypobaric hypoxia in wistar rats |
|---|---|
| المؤلفون: | Arriaza, Karem, Brito, Julio, Siques, Patricia, Flores, Karen, Ordenes, Stefany, Aguayo, Daniel, López, María del Rosario, Arribas Rodríguez, Silvia Magdalena |
| المساهمون: | UAM. Departamento de Fisiología |
| بيانات النشر: | MDPI |
| سنة النشر: | 2023 |
| المجموعة: | Universidad Autónoma de Madrid (UAM): Biblos-e Archivo |
| مصطلحات موضوعية: | hypobaric hypoxia, hypoxic pulmonary vasoconstriction, right ventricle hypertrophy, zinc, Medicina |
| الوصف: | Hypobaric hypoxia under chromic conditions triggers hypoxic pulmonary vasoconstriction (HPV) and right ventricular hypertrophy (RVH). The role of zinc (Zn) under hypoxia is controversial and remains unclear. We evaluated the effect of Zn supplementation in prolonged hypobaric hypoxia on HIF2α/MTF-1/MT/ZIP12/PKCε pathway in the lung and RVH. Wistar rats were exposed to hypobaric hypoxia for 30 days and randomly allocated into three groups: chronic hypoxia (CH); intermittent hypoxia (2 days hypoxia/2 days normoxia; CIH); and normoxia (sea level control; NX). Each group was subdivided (n = 8) to receive either 1% Zn sulfate solution (z) or saline (s) intraperitoneally. Body weight, hemoglobin, and RVH were measured. Zn levels were evaluated in plasma and lung tissue. Additionally, the lipid peroxidation levels, HIF2α/MTF-1/MT/ZIP12/PKCε protein expression and pulmonary artery remodeling were measured in the lung. The CIH and CH groups showed decreased plasma Zn and body weight and increased hemoglobin, RVH, and vascular remodeling; the CH group also showed increased lipid peroxidation. Zn administration under hypobaric hypoxia upregulated the HIF2α/MTF-1/MT/ZIP12/PKCε pathway and increased RVH in the intermittent zinc group. Under intermittent hypobaric hypoxia, Zn dysregulation could participate in RVH development through alterations in the pulmonary HIF2α/MTF1/MT/ZIP12/PKCε pathway |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | International Journal of Molecular Sciences; https://doi.org/10.3390/ijms24119567; International Journal of Molecular Sciences 24.11 (2023): 9567; 1422-0067 (online); http://hdl.handle.net/10486/708580; 9567-1; 11; 9567-20; 24 |
| DOI: | 10.3390/ijms24119567 |
| الاتاحة: | http://hdl.handle.net/10486/708580 https://doi.org/10.3390/ijms24119567 |
| Rights: | © 2023 by the authors ; Reconocimiento ; openAccess |
| رقم الانضمام: | edsbas.17DA8F45 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ijms24119567 |
|---|