Academic Journal
Study on the antinociceptive activity and mechanism of action of isolated saponins from siolmatra brasiliensis (Cogn.) Baill
| العنوان: | Study on the antinociceptive activity and mechanism of action of isolated saponins from siolmatra brasiliensis (Cogn.) Baill |
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| المؤلفون: | Boylan, Fabio, Giorno, Thais Biondino Sardella, dos Santos, Carlos Henrique Corr?a, de Carvalho, Mario Geraldo, da Silva, Virg?nia Cl?udia, de Sousa Jr., Paulo Teixeria, Fernandes, Patricia Dias |
| سنة النشر: | 2019 |
| المجموعة: | The University of Dublin, Trinity College: TARA (Trinity's Access to Research Archive) |
| مصطلحات موضوعية: | Siolmatra brasiliensis (Cogn.) Baill, (?taiui??, ?cip?-tau??), Antinociceptive activity, Cayaponoside A1, Cayapanoside B4, Cayapanoside D, Siolmatroside I, Pain, Analgesia |
| الوصف: | Infusions of roots of Siolmatra brasiliensis (Cogn.) Baill, (?taiui??, ?cip?-tau??) are used for toothache pain and ulcers. We aimed to study the antinociceptive effects and identify the possible mechanism of action of this plant and its isolated substances (cayaponoside A1, cayaponoside B4, cayaponoside D, and siolmatroside I). Hydroethanol extract (HE), ethyl acetate fraction (EtOAc), and isolated saponins were evaluated in chemical and thermal models of pain in mice. Animals were orally pretreated and evaluated in the capsaicin- or glutamate-induced licking and in the hot plate tests. The antinociceptive mechanism of action was evaluated using the hot plate test with the following pretreatments: Atropine (cholinergic antagonist), naloxone (opioid antagonist), or L-NAME (nitric oxide synthase inhibitor). All extracts and isolated saponins increased the area under the curve in the hot plate test. Tested substances induced a higher effect than the morphine-treated group. Our data suggest that stems of S. brasiliensis and their isolated substances present antinociceptive effects. Cholinergic and opioidergic pathways seem to be involved in their mechanism of action. Taken together our data corroborate the traditional use of the plant and expands the information regarding its use |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | Molecules; 24; Giorno, T.B.S., dos Santos, C.H.C., de Carvalho, M.G., da Silva, V.C., de Sousa, P.T., Fernandes, P.D. & Boylan, F., Study on the antinociceptive activity and mechanism of action of isolated saponins from siolmatra brasiliensis (Cogn.) Baill, Molecules, 24, 24, 2019; Y; https://www.mdpi.com/1420-3049/24/24/4584; http://hdl.handle.net/2262/91332; http://people.tcd.ie/desouzaf; 210060; http://dx.doi.org/10.3390/molecules24244584; orcid:0000-0001-5531-1787 |
| DOI: | 10.3390/molecules24244584 |
| الاتاحة: | http://hdl.handle.net/2262/91332 https://www.mdpi.com/1420-3049/24/24/4584 http://people.tcd.ie/desouzaf https://doi.org/10.3390/molecules24244584 |
| Rights: | Y ; openAccess |
| رقم الانضمام: | edsbas.17B3290D |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/molecules24244584 |
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