Academic Journal
The ability of high dose rosuvastatin to improve plaque composition in non-intervened coronary arteries: Rationale and design of the Integrated Biomarker and Imaging Study-3 (IBIS-3)
| العنوان: | The ability of high dose rosuvastatin to improve plaque composition in non-intervened coronary arteries: Rationale and design of the Integrated Biomarker and Imaging Study-3 (IBIS-3) |
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| المؤلفون: | Simsek, C. (Cihan), Garcia-Garcia, H.M. (Hector), Geuns, R.J.M. (Robert Jan) van, Magro, M. (Michael), Girasis, C. (Chrysafios), Mieghem, N.M. (Nicolas) van, Lenzen, M.J. (Mattie), Boer, S.P.M. (Sanneke) de, Regar, E.S. (Eveline), Giessen, W.J. (Wim) van der, Raichlen, J. (Joel), Duckers, H.J. (Henricus), Zijlstra, F. (Felix), Steen, A.F.W. (Ton) van der, Boersma, H. (Eric), Serruys, P.W.J.C. (Patrick) |
| المصدر: | EuroIntervention vol. 8 no. 2, pp. 235-241 |
| سنة النشر: | 2012 |
| المجموعة: | RePub - Publications from Erasmus University, Rotterdam |
| مصطلحات موضوعية: | Intravascular ultrasound-virtual histology, Near-infrared spectroscopy, Percutaneous coronary intervention, Rosuvastatin |
| الوصف: | Aims: Acute coronary syndromes (ACS) are often caused by rupture of non-flow limiting "vulnerable" atherosclerotic plaque, characterised by a large necrotic core pool and a thin, inflamed fibrous cap that are unidentifiable with diagnostic coronary angiography. The implementation of novel invasive imaging modalities, such as intravascular ultrasound-virtual histology (IVUS-VH) and near-infrared spectroscopy (NIRS), could help identify high-risk patients who are in need of aggressive medical therapy. The intake of high dose rosuvastatin has been shown to reduce plaque containing necrotic core in the carotid arteries, however it remains unknown whether there is a similar effect in the coronary arteries. Methods and results: The IBIS-3 study is a single centre, non-randomised study designed to evaluate the ability of 12-months high dose rosuvastatin treatment (40 mg daily po) to reduce the necrotic core of a nonintervened coronary segment assessed with IVUS-VH. All patients undergoing diagn |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | http://repub.eur.nl/pub/74714; urn:hdl:1765/74714 |
| DOI: | 10.4244/EIJV8I2A37 |
| الاتاحة: | http://repub.eur.nl/pub/74714 https://doi.org/10.4244/EIJV8I2A37 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.1796E501 |
| قاعدة البيانات: | BASE |
| DOI: | 10.4244/EIJV8I2A37 |
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