Academic Journal
外周血淋巴细胞亚群监测对复发转移性乳腺癌的预测及预后价值 ; Predictive and prognostic value of monitoring lymphocyte subsets in peripheral blood before and after chemotherapy in patients with metastatic breast cancer
| العنوان: | 外周血淋巴细胞亚群监测对复发转移性乳腺癌的预测及预后价值 ; Predictive and prognostic value of monitoring lymphocyte subsets in peripheral blood before and after chemotherapy in patients with metastatic breast cancer |
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| المؤلفون: | 邵彬, 李惠平, 邸立军, 宋国红, 姜晗窻, 梁旭, 王超颖, 严颖, 林晓琳, 王丽娜, 宛凤玲, 袁艳华, 尤渺宁 |
| المساهمون: | 北京大学临床肿瘤学院，北京肿瘤医院暨北京市肿瘤防治研究所乳腺肿瘤内科，恶性肿瘤发病机制及转化研究教育部重点实验室，北京 100142 |
| المصدر: | 万方 ; 知网 ; CSCD ; PubMed ; http://d.g.wanfangdata.com.cn/Periodical_bjykdxxx201602025.aspx |
| بيانات النشر: | 北京大学学报 医学版 |
| سنة النشر: | 2016 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | 乳腺肿瘤, 肿瘤转移, 淋巴细胞亚群, 预后, Breast neoplasms, Neoplasm metastasis, Lymphocyte subsets, Prognosis |
| الوصف: | 目的：检测化疗前、化疗2周期评价疗效时复发转移性乳腺癌患者外周血淋巴细胞亚群比率，探讨外周血淋巴细胞亚群比率与患者化疗近期疗效及预后的关系。方法：采用流式细胞术检测83例复发转移性乳腺癌患者化疗前、化疗2周期评价疗效时外周血中CD3＋T细胞、CD3＋／CD4＋T细胞、CD3＋／CD8＋T细胞、CD3－／CD16＋56＋自然杀伤细胞（natural killer，NK）细胞、CD3＋／CD16＋56＋T细胞、CD19＋B细胞、CD4＋／CD25＋调节性T细胞（regulatory T cells，Treg）细胞、CD8＋／CD28－T细胞和CD8＋／CD28＋T细胞比率，结合临床病理进行统计。结果：疾病控制患者（部分缓解＋稳定）化疗后CD4＋／CD25＋Treg细胞比率变化较疾病进展患者显著下降（P＝0．034）。化疗后Treg细胞比率变化显著影响患者总生存期（P＜0．05），化疗后Treg细胞比率降低的患者较升高的患者总生存期显著延长，分别为23．5及9．4个月。结论：复发转移性乳腺癌患者化疗后Treg细胞比率降低者化疗近期疗效及预后较好。 ; Objective:To detect the proportion of lymphocyte subsets in peripheral blood of the ad-vanced breast cancer patients before and after chemotherapy with docetaxel and thiotepa,as well as the association between the proportion of peripheral blood lymphocyte subsets with the response rate and prog-nosis.Methods:The proportions of lymphocyte subsets (CD3 +T cell,CD3 +/CD4 +T cell,CD3 +/CD8 +T cell,CD3 -/CD16 +56 +NK cell,CD3 +/CD16 +56 +T cell,CD19 +B cell,CD4 +/CD25 +T cell,CD8 +/CD28 -T cell,CD8 +/CD28 +T cell)in the peripheral blood of 86 patients were analyzed with flowcytometry before and after chemotherapy.The result was analyzed in combination with clinico-pathological data.Results:The proportion of regulatory T cells (Treg)after chemotherapy in the disease control patients decreased significantly compared with that of the progressive patients (P=0.034).The difference of the proportions of Treg before and after chemotherapy affected significantly the overall survi-val (OS).The OS of the patients with decreased proportion of Treg was significantly longer than that of the patients with increased proportion of Treg,which was 23.5 and 9.4 months respectively (P<0.05). Conclusion:The patients with decreased proportion of Treg after chemotherapy had higher response rate and better survival benefit. ; PubMed ; 中文核心期刊要目总览(PKU) ; 中国科技核心期刊(ISTIC) ; 中国科学引文数据库(CSCD) ; 2 ; 304-309 ; 48 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | Chinese |
| تدمد: | 1671-167X |
| Relation: | 北京大学学报（医学版）.2016,48(2),304-309.; 1389982; http://hdl.handle.net/20.500.11897/434120 |
| DOI: | 10.3969/j.issn.1671-167X.2016.02.023 |
| الاتاحة: | https://hdl.handle.net/20.500.11897/434120 https://doi.org/10.3969/j.issn.1671-167X.2016.02.023 |
| رقم الانضمام: | edsbas.1747A5D9 |
| قاعدة البيانات: | BASE |
| تدمد: | 1671167X |
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| DOI: | 10.3969/j.issn.1671-167X.2016.02.023 |