Academic Journal
Diagnostic value of VEGF in peri-implantitis and its correlation with titanium particles: A controlled clinical study
| العنوان: | Diagnostic value of VEGF in peri-implantitis and its correlation with titanium particles: A controlled clinical study |
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| المؤلفون: | Rakic, Mia, Canullo, Luigi, Radovanovic, Sandro, Tatic, Zoran, Radunovic, Milena, Souedain, Assem, Weiss, Pierre, Struillou, Xavier, Vojvodic, Danilo |
| المساهمون: | Regenerative Medicine and Skeleton (RMeS), École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Département de parodontologie UNIV Nantes (Faculté de chirurgie dentaire), Université de Nantes (UN), Private Practice Rome, Italy, Faculty of Organizational Sciences (FOS), University of Belgrade Belgrade, École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR Odontologie (Nantes Univ – UFR Odonto), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ) |
| المصدر: | ISSN: 0109-5641 ; Dental Materials ; https://nantes-universite.hal.science/hal-04593363 ; Dental Materials, 2024, 40 (1), pp.28-36. ⟨10.1016/j.dental.2023.10.003⟩. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2024 |
| المجموعة: | Université de Nantes: HAL-UNIV-NANTES |
| مصطلحات موضوعية: | Peri-implantitis, VEGF, Biomarker, Diagnosis, Titanium particles, Machine learning algorithms, Peri-implantitis VEGF Biomarker Diagnosis Titanium particles Machine learning algorithms, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| الوصف: | International audience ; Objectives: VEGF is prototypic marker of neovascularization, repeatedly proposed as intrinsic characteristic of peri-implantitis. This study aimed to assess pattern of VEGF in peri-implantitis, its correlation with titanium particles (TPs) and capacity as respective biomarker.Material and methods: Pathological specificity of VEGF was assessed in peri-implant granulations using immunohistochemistry, periodontal granulations represented Ti-free positive controls. VEGF was correlated to TPs, identified using scanning electron microscopy coupled with dispersive x-ray spectrometry. Diagnostic accuracy, sensitivity and specificity of VEGF were estimated in PICF specimens from peri-implantitis, peri-implant mucositis (PIM) and healthy peri-implant tissues (HI) using machine learning algorithms.Results: Peri-implantitis exhibited rich neovascular network with expressed density in contact zones toward neutrophil infiltrates without specific pattern variations around TPs, identified in all peri-implantitis specimens (mean particle size 8.9 ± 24.8 μm2; Ti-mass (%) 0.380 ± 0.163). VEGF was significantly more expressed in peri-implantitis (47,065 ± 24.2) compared to periodontitis (31,14 ± 9.15), and positively correlated with its soluble concentrations in PICF (p = 0.01). VEGF was positively correlated to all clinical endpoints and significantly increased in peri-implantitis compared to both PIM and HI, but despite high specificity (96%), its overall diagnostic capacity was average. Two patient clusters were identified in peri-implantitis, one with 8-fold higher VEGF values compared to HI, and second with lower values comparable to PIM.Significance: VEGF accurately reflects neovascularization in peri-implantitis that was expressed in contact zones toward implant surface without specific histopathological patter variation around TPs. VEGF answered requests for biomarker of peri-implantitis but further research is necessary to decrypt its exact underlying cause. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/37865576; hal-04593363; https://nantes-universite.hal.science/hal-04593363; https://nantes-universite.hal.science/hal-04593363/document; https://nantes-universite.hal.science/hal-04593363/file/Dental%20Materials.pdf; PUBMED: 37865576 |
| DOI: | 10.1016/j.dental.2023.10.003 |
| الاتاحة: | https://nantes-universite.hal.science/hal-04593363 https://nantes-universite.hal.science/hal-04593363/document https://nantes-universite.hal.science/hal-04593363/file/Dental%20Materials.pdf https://doi.org/10.1016/j.dental.2023.10.003 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.173D11EF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.dental.2023.10.003 |
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