Academic Journal
Exenatide regulates pancreatic islet integrity and insulin sensitivity in the nonhuman primate baboon Papio hamadryas.
| العنوان: | Exenatide regulates pancreatic islet integrity and insulin sensitivity in the nonhuman primate baboon Papio hamadryas. |
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| المؤلفون: | Fiorentino, T.V., Casiraghi, F., Davalli, A.M., Finzi, G., La Rosa, S., Higgins, P.B., Abrahamian, G.A., Marando, A., Sessa, F., Perego, C., Guardado-Mendoza, R., Kamath, S., Ricotti, A., Fiorina, P., Daniele, G., Paez, A.M., Andreozzi, F., Bastarrachea, R.A., Comuzzie, A.G., Gastaldelli, A., Chavez, A.O., Di Cairano, E.S., Frost, P., Luzi, L., Dick, E.J., Halff, G.A., DeFronzo, R.A., Folli, F. |
| المصدر: | JCI insight, vol. 4, no. 20, pp. e93091 |
| سنة النشر: | 2019 |
| المجموعة: | Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| مصطلحات موضوعية: | Animals, Apoptosis/drug effects, Blood Glucose/analysis, Cell Proliferation/drug effects, Cell Transdifferentiation/drug effects, Diabetes Mellitus, Type 2/blood, Type 2/drug therapy, Type 2/pathology, Disease Models, Animal, Exenatide/pharmacology, Exenatide/therapeutic use, Female, Glucose Clamp Technique, Humans, Hypoglycemic Agents/pharmacology, Hypoglycemic Agents/therapeutic use, Infusions, Intravenous, Insulin/metabolism, Insulin Resistance, Islets of Langerhans/drug effects, Islets of Langerhans/pathology, Male, Papio, B cells, Endocrinology, Glucose metabolism, Insulin signaling |
| الوصف: | The glucagon-like peptide-1 receptor agonist exenatide improves glycemic control by several and not completely understood mechanisms. Herein, we examined the effects of chronic intravenous exenatide infusion on insulin sensitivity, β cell and α cell function and relative volumes, and islet cell apoptosis and replication in nondiabetic nonhuman primates (baboons). At baseline, baboons received a 2-step hyperglycemic clamp followed by an l-arginine bolus (HC/A). After HC/A, baboons underwent a partial pancreatectomy (tail removal) and received a continuous exenatide (n = 12) or saline (n = 12) infusion for 13 weeks. At the end of treatment, HC/A was repeated, and the remnant pancreas (head-body) was harvested. Insulin sensitivity increased dramatically after exenatide treatment and was accompanied by a decrease in insulin and C-peptide secretion, while the insulin secretion/insulin resistance (disposition) index increased by about 2-fold. β, α, and δ cell relative volumes in exenatide-treated baboons were significantly increased compared with saline-treated controls, primarily as the result of increased islet cell replication. Features of cellular stress and secretory dysfunction were present in islets of saline-treated baboons and absent in islets of exenatide-treated baboons. In conclusion, chronic administration of exenatide exerts proliferative and cytoprotective effects on β, α, and δ cells and produces a robust increase in insulin sensitivity in nonhuman primates. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/31536476; info:eu-repo/semantics/altIdentifier/eissn/2379-3708; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_893519A0D48A4; https://serval.unil.ch/notice/serval:BIB_893519A0D48A; https://serval.unil.ch/resource/serval:BIB_893519A0D48A.P001/REF.pdf |
| DOI: | 10.1172/jci.insight.93091 |
| الاتاحة: | https://serval.unil.ch/notice/serval:BIB_893519A0D48A https://doi.org/10.1172/jci.insight.93091 https://serval.unil.ch/resource/serval:BIB_893519A0D48A.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_893519A0D48A4 |
| Rights: | info:eu-repo/semantics/openAccess ; CC BY 4.0 ; https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.1708C401 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1172/jci.insight.93091 |
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