Academic Journal
Whole blood viscoelastic testing profile and mortality in patients hospitalized with acute COVID-19 pneumonia: A systematic review and meta-analysis
| العنوان: | Whole blood viscoelastic testing profile and mortality in patients hospitalized with acute COVID-19 pneumonia: A systematic review and meta-analysis |
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| المؤلفون: | Spiezia, Luca, Campello, Elena, Simioni, Paolo, Lumbreras-Marquez, Mario I. |
| المساهمون: | Spiezia, Luca, Campello, Elena, Simioni, Paolo, Lumbreras-Marquez, Mario I. |
| بيانات النشر: | Elsevier Ltd |
| سنة النشر: | 2024 |
| المجموعة: | Padua Research Archive (IRIS - Università degli Studi di Padova) |
| مصطلحات موضوعية: | Acute COVID-19 pneumonia, Metaanalysi, Mortality, Whole blood viscoelastic testing profile |
| الوصف: | Background: Several studies have evaluated the possible association between whole blood viscoelastic testing (VET) parameters in patients hospitalized for acute Coronavirus disease 2019 (COVID-19) pneumonia and mortality. A few studies found no significant differences between survivors and non-survivors, though other studies identified potential predictors of COVID-19-related mortality. We conducted a systematic review and meta-analysis of the literature to evaluate the possible association between standard thromboelastometry/graphy parameters and mortality in patients hospitalized for acute COVID-19 pneumonia. Methods: Relevant studies were searched through MEDLINE, EMBASE, and Google Scholar from their inception until 15th June 2023. We aimed to identify any study including: i) adults admitted to intensive care units (ICU) or medicine wards (MW) for acute COVID-19 pneumonia; ii) viscoelastic testing; iii) mortality. Results: We included 13 studies: nine prospective and four retrospective, 231 (30.4 %) non-survivors and 528 (69.6 %) survivors. Mortality rates ranged from 12.8 % to 67.5 %. The studies using the TEG apparatus found a significant difference in K time in the Kaolin test among survivors vs. non-survivors (mean difference [MD] 0.20, 95 % confidence interval [CI] 0.12, 0.28, I2 0%). The studies using the rotational thromboelastometry apparatus found a significant difference in CT-INTEM (MD −17.14, 95 % CI −29.23, −5.06, I2 0%) and LI60-EXTEM (MD −1.00, 95 % CI −1.00, −1.00, I2 0%) assays among survivors vs. non-survivors. Conclusion: We identified no specific hypercoagulable or hypocoagulable profile associated with mortality in patients with COVID-19-related pneumonia. Large prospective studies are needed to explore the possible prognostic role of VET in this subset of patients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/38142487; volume:234; firstpage:21; lastpage:31; numberofpages:11; journal:THROMBOSIS RESEARCH; https://hdl.handle.net/11577/3504267; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85180602724 |
| DOI: | 10.1016/j.thromres.2023.12.009 |
| الاتاحة: | https://hdl.handle.net/11577/3504267 https://doi.org/10.1016/j.thromres.2023.12.009 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.17065910 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.thromres.2023.12.009 |
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