Academic Journal
Subarachnoid Administration of Iohexol in Cynomolgus Monkeys
| العنوان: | Subarachnoid Administration of Iohexol in Cynomolgus Monkeys |
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| المؤلفون: | Drobeck, H. P., Mayes, B. A., Barbolt, T. A., Fabian, R. J., Kimball, J. P., Slighter, R. R. |
| المصدر: | Acta Radiologica. Diagnosis ; volume 27, issue 3, page 349-355 ; ISSN 0567-8056 |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 1986 |
| الوصف: | A non-ionic diagnostic medium, iohexol, was administered by subarachnoid injection to groups of six cynomolgus monkeys and compared with the vehicle, physiologically normal saline, and/or saline of equal osmolality to determine its potential for increasing total protein and leucocyte levels in cerebrospinal fluid. Also investigated was the effect of repeated spinal taps not subsequently followed by the intrathecal injection of test or control articles. In the monkey, unlike man, low-level leucocyte counts were consistently observed following initial withdrawal of spinal fluid. Elevated leucocyte and total protein levels were observed in the present investigations one day to a week after intrathecal injection of radiopaque, vehicle or saline solution. Total protein returned to normal levels earlier than did leucocyte counts. However, repeated needle puncture alone was found to be sufficient to cause an elevation of leucocytes 3 to 4 times the baseline level, while inflammatory effects were observed histologically only when autopsy was performed soon after the final spinal tap. References |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1177/028418518602700317 |
| الاتاحة: | https://doi.org/10.1177/028418518602700317 https://journals.sagepub.com/doi/pdf/10.1177/028418518602700317 |
| Rights: | https://journals.sagepub.com/page/policies/text-and-data-mining-license |
| رقم الانضمام: | edsbas.16F96B2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/028418518602700317 |
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