التفاصيل البيبلوغرافية
| العنوان: |
Short-term hypoxia in cells induces expression of genes which are enhanced in stressed cells / |
| المؤلفون: |
Pečiulienė, Inga, Jakubauskienė, Eglė, Vilys, Laurynas, Zinkevičiūtė, Rūta, Kvederavičiūtė, Kotryna, Kanopka, Arvydas |
| المصدر: |
Genes., Basel : MDPI, 2022, vol. 13, iss. 9, art. no. 1596, p. [1-15]. ; eISSN 2073-4425 |
| سنة النشر: |
2022 |
| المجموعة: |
Vilnius University Virtual Library (VU VL) / Vilniaus universitetas virtuali biblioteka |
| مصطلحات موضوعية: |
RNA, SR proteins, hypoxia, kinases, phosphatases, splicing |
| الوصف: |
All living organisms must respond to, and defend against, environmental stresses. Depending on the extent and severity of stress, cells try to alter their metabolism and adapt to a new state. Changes in alternative splicing of pre-mRNA are a crucial regulation mechanism through which cells are able to respond to a decrease in oxygen tension in the cellular environment. Currently, only limited data are available in the literature on how short-term hypoxia influences mRNA isoform formation. In this work, we discovered that expressions of the same genes that are activated during cellular stress are also activated in cells under short-term hypoxic conditions. Our results demonstrate that short-term hypoxia influences the splicing of genes associated with cell stress and apoptosis; however, the mRNA isoform formation patterns from the same pre-mRNAs in cells under short-term hypoxic conditions and prolonged hypoxia are different. Obtained data also show that short-term cellular hypoxia increases protein phosphatase but not protein kinase expression. Enhanced levels of protein phosphatase expression in cells are clearly important for changing mRNA isoform formation. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
https://epublications.vu.lt/object/elaba:146854820/146854820.pdf; https://repository.vu.lt/VU:ELABAPDB146854820&prefLang=en_US |
| الاتاحة: |
https://repository.vu.lt/VU:ELABAPDB146854820&prefLang=en_US |
| Rights: |
info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.16F3ACE7 |
| قاعدة البيانات: |
BASE |