Academic Journal
Axo-glial interactions between midbrain dopamine neurons and oligodendrocyte lineage cells in the anterior corpus callosum
| العنوان: | Axo-glial interactions between midbrain dopamine neurons and oligodendrocyte lineage cells in the anterior corpus callosum |
|---|---|
| المؤلفون: | Caldwell, Megan, Ayo-Jibunoh, Vanessa, Mendoza, Josue Criollo, Brimblecombe, Katherine R., Reynolds, Lauren M., Zhu Jiang, Xin Yan, Alarcon, Colin, Fiore, Elizabeth, N. Tomaio, Jacquelyn, Phillips, Greg R., Mingote, Susana, Flores, Cecilia, Casaccia, Patrizia, Liu, Jia, Cragg, Stephanie J., McCloskey, Dan P., Yetnikoff, Leora |
| المساهمون: | Parkinson’s UK, National Institute on Drug Abuse at the National Institute of Health, Wellcome Trust, Aligning Science Across Parkinson’s, Medical Research Council, National Institute of Neurological Disorders and Stroke at the National Institute of Health |
| المصدر: | Brain Structure and Function ; volume 228, issue 8, page 1993-2006 ; ISSN 1863-2661 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2023 |
| الوصف: | Oligodendrocyte progenitor cells (OPCs) receive synaptic innervation from glutamatergic and GABAergic axons and can be dynamically regulated by neural activity, resulting in activity-dependent changes in patterns of axon myelination. However, it remains unclear to what extent other types of neurons may innervate OPCs. Here, we provide evidence implicating midbrain dopamine neurons in the innervation of oligodendrocyte lineage cells in the anterior corpus callosum and nearby white matter tracts of male and female adult mice. Dopaminergic axon terminals were identified in the corpus callosum of DAT-Cre mice after injection of an eYFP reporter virus into the midbrain. Furthermore, fast-scan cyclic voltammetry revealed monoaminergic transients in the anterior corpus callosum, consistent with the anatomical findings. Using RNAscope, we further demonstrate that ~ 40% of Olig2 + /Pdfgra + cells and ~ 20% of Olig2 + /Pdgfra- cells in the anterior corpus callosum express Drd1 and Drd2 transcripts. These results suggest that oligodendrocyte lineage cells may respond to dopamine released from midbrain dopamine axons, which could affect myelination. Together, this work broadens our understanding of neuron-glia interactions with important implications for myelin plasticity by identifying midbrain dopamine axons as a potential regulator of corpus callosal oligodendrocyte lineage cells. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1007/s00429-023-02695-y |
| DOI: | 10.1007/s00429-023-02695-y.pdf |
| DOI: | 10.1007/s00429-023-02695-y/fulltext.html |
| الاتاحة: | http://dx.doi.org/10.1007/s00429-023-02695-y https://link.springer.com/content/pdf/10.1007/s00429-023-02695-y.pdf https://link.springer.com/article/10.1007/s00429-023-02695-y/fulltext.html |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.16C8518 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00429-023-02695-y |
|---|