Academic Journal
Physical activity, sedentary behaviour and risk of oesophago-gastric cancer: a prospective cohort study within UK Biobank
| العنوان: | Physical activity, sedentary behaviour and risk of oesophago-gastric cancer: a prospective cohort study within UK Biobank |
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| المؤلفون: | Kunzmann, Andrew T., Mallon, Kristian P., Hunter, Ruth F., Cardwell, Chris. R., McMenamin, Úna C., Spence, Andrew D., Coleman, Helen G. |
| المصدر: | Kunzmann , A T , Mallon , K P , Hunter , R F , Cardwell , C R , McMenamin , Ú C , Spence , A D & Coleman , H G 2018 , ' Physical activity, sedentary behaviour and risk of oesophago-gastric cancer: a prospective cohort study within UK Biobank ' , United European Gastroenterology Journal , vol. 6 , no. 8 , pp. 1144-1154 . https://doi.org/10.1177/2050640618783558 |
| سنة النشر: | 2018 |
| المجموعة: | Queen's University Belfast: Research Portal |
| مصطلحات موضوعية: | /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being |
| الوصف: | Background: Few observational studies have assessed the role of physical activity in oesophago-gastric cancer risk. Objective: This prospective cohort study aimed to assess the association between physical activity and risk of oesophageal or gastric cancer. Methods: A cohort of 359,033 adults aged 40-69 years were identified from the UK Biobank, which recruited participants between 2006 and 2010. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations between self-reported levels of physical activity and screen-based sedentary behaviour, and risk of oesophageal and gastric cancer were calculated using Cox proportional hazards models. Results: During 8 years of follow-up (mean=5.5), 294 oesophageal cancer and 217 gastric cancer cases were identified. Physical activity and screen-based sedentary behaviour levels were not associated with overall oesophago-gastric cancer risk. However, when compared with low levels, high physical activity levels were associated with a significantly reduced risk of gastric non-cardia cancer (HR 0.58, 95% CI 0.37- 0.95). Moderate physical activity levels were associated with a 38% reduced risk of oesophageal adenocarcinoma (HR 0.62, 95% CI 0.43-0.89), although no doseresponse association was apparent. Conclusion: Moderate, rather than high, physical activity levels were associated with the strongest reductions in oesophageal adenocarcinoma risk in this large UK prospective cohort. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1177/2050640618783558 |
| الاتاحة: | https://pure.qub.ac.uk/en/publications/c72e7b8f-2c42-4520-ba77-2af99da4e7eb https://doi.org/10.1177/2050640618783558 https://pureadmin.qub.ac.uk/ws/files/151769216/PA_Oesophago_Gastric_Cancer_UNITED_EUR_GAST_J_after_review_FINAL.pdf |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.16B21649 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/2050640618783558 |
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