Academic Journal
Risk of non alcoholic steatohepatitis and fibrosis in patients with non alcoholic fatty liver disease and low visceral adiposity
| العنوان: | Risk of non alcoholic steatohepatitis and fibrosis in patients with non alcoholic fatty liver disease and low visceral adiposity |
|---|---|
| المؤلفون: | Fracanzani AL, Valenti L, Grieco A, Miele L, Consonni D, Fatta E, Lombardi R, Marchesini G, Fargion S., BUGIANESI, Elisabetta, VANNI, Ester |
| المساهمون: | Fracanzani AL, Valenti L, Bugianesi E, Vanni E, Grieco A, Miele L, Consonni D, Fatta E, Lombardi R, Marchesini G, Fargion S. |
| سنة النشر: | 2011 |
| المجموعة: | Università degli studi di Torino: AperTo (Archivio Istituzionale ad Accesso Aperto) |
| مصطلحات موضوعية: | NASH, visceral obesity |
| الوصف: | BACKGROUND AND AIMS: Increased visceral adiposity is considered the hallmark of the metabolic syndrome, whose hepatic manifestation is nonalcoholic fatty liver disease (NAFLD), although a subset of patients does not have visceral obesity. Aim: To compare metabolic alterations and liver damage in patients with NAFLD with and without visceral obesity. METHODS: 431 consecutive patients with liver biopsy-confirmed NAFLD were divided in three groups according to waist circumference, the simplest surrogate marker of visceral obesity. One hundred and thirty three (31%) had waist circumference ⩽ 94 (males) and ⩽ 80 cm (females) (group A), 157 (36%) between 94 and 102 and 80 and 88 (B), and the remaining 141 (33%) values higher than 102 and 88 cm (C). RESULTS: Significant trends for older age, higher prevalence of female sex , lower HDL, higher triglycerides, altered glucose metabolism, hypertension and metabolic syndrome were observed with increasing visceral adiposity. In contrast, non-alcoholic steatohepatitis (NASH) detected in 55% and 72% of patients with normal and increased waist circumference and the presence of fibrosis >2 were not associated with visceral adiposity. Alanine aminotransferase (ALT), ferritin, HOMA-IR > 4, and severe steatosis were independently associated with NASH, whereas ferritin and impaired glucose tolerance were associated with fibrosis >2. CONCLUSION: Patients with normal waist circumference, despite milder metabolic alterations, may have NASH and are at risk of developing fibrosis, suggesting that once NAFLD is present, visceral obesity is not a major determinant of liver damage severity. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/21145841; info:eu-repo/semantics/altIdentifier/wos/WOS:000291523000023; volume:54 (6); firstpage:1244; lastpage:1249; numberofpages:6; journal:JOURNAL OF HEPATOLOGY; info:eu-repo/grantAgreement/EC/FP7/241762; http://hdl.handle.net/2318/83956; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-79956117037; http://www.ncbi.nlm.nih.gov/pubmed |
| الاتاحة: | http://hdl.handle.net/2318/83956 http://www.ncbi.nlm.nih.gov/pubmed |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.169D67D7 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |