Academic Journal
Resveratrol Inhibits Neointimal Growth after Arterial Injury in High-Fat-Fed Rodents: The Roles of SIRT1 and AMPK
| العنوان: | Resveratrol Inhibits Neointimal Growth after Arterial Injury in High-Fat-Fed Rodents: The Roles of SIRT1 and AMPK |
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| المؤلفون: | Guo, June, Pereira, Troy J, Mori, Yusaku, Gonzalez Medina, Marel, Breen, Danna M, Dalvi, Prasad S, Zhang, Hangjun, McCole, Declan F, McBurney, Michael W, Heximer, Scott P, Tsiani, Evangelia L, Dolinsky, Vernon W, Giacca, Adria |
| بيانات النشر: | University of Toronto |
| سنة النشر: | 2020 |
| المجموعة: | University of Toronto: Research Repository T-Space |
| مصطلحات موضوعية: | Insulin resistance, Femoral wire injury, Carotid balloon injury, Restenosis |
| الوصف: | We have shown that both insulin and resveratrol (RSV) decrease neointimal hyperplasia in chow-fed rodents via mechanisms that are in part overlapping and involve the activation of endothelial nitric oxide synthase (eNOS). However, this vasculoprotective effect of insulin is abolished in high-fat-fed insulin-resistant rats. Since RSV, in addition to increasing insulin sensitivity, can activate eNOS via pathways that are independent of insulin signaling, such as the activation of sirtuin 1 (SIRT1) and AMP-activated kinase (AMPK), we speculated that unlike insulin, the vasculoprotective effect of RSV would be retained in high-fat-fed rats. We found that high-fat feeding decreased insulin sensitivity and increased neointimal area and that RSV improved insulin sensitivity (p < 0.05) and decreased neointimal area in high-fat-fed rats (p < 0.05). We investigated the role of SIRT1 in the effect of RSV using two genetic mouse models. We found that RSV decreased neointimal area in high-fat-fed wild-type mice (p < 0.05), an effect that was retained in mice with catalytically inactive SIRT1 (p < 0.05) and in heterozygous SIRT1-null mice. In contrast, the effect of RSV was abolished in AMKPα2-null mice. Thus, RSV decreased neointimal hyperplasia after arterial injury in both high-fat-fed rats and mice, an effect likely not mediated by SIRT1 but by AMPKα2. ; Funding provided by grants to A.G. from the Heart and Stroke Foundation of Canada (Grants #T-7342, #G-13-0001610, and G-18-0022151). J.G. and D.M.B. were supported by Banting and Best Diabetes Centre/Novo Nordisk Studentships, Heart & Stroke Foundation of Ontario Graduate Scholarships, Ontario Graduate Scholarships, and Canadian Diabetes Association Doctoral Stu- dent Research Awards. J.G. was also a member of the Cardiovas- cular Sciences Collaborative Programs. Y.M. was supported by Showa University Research Grant for Young Researchers. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1018-1172 |
| Relation: | Guo, J., Pereira, T. J., Mori, Y., Medina, M. G., Breen, D. M., Dalvi, P. S., . & Tsiani, E. L. (2020). Resveratrol Inhibits Neointimal Growth after Arterial Injury in High-Fat-Fed Rodents: The Roles of SIRT1 and AMPK. Journal of Vascular Research, 57(6), 325-340.; http://hdl.handle.net/1807/103994 |
| DOI: | 10.1159/000509217 |
| الاتاحة: | http://hdl.handle.net/1807/103994 https://doi.org/10.1159/000509217 |
| Rights: | Attribution-NonCommercial-NoDerivatives 4.0 International ; http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| رقم الانضمام: | edsbas.1667F30B |
| قاعدة البيانات: | BASE |
| تدمد: | 10181172 |
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| DOI: | 10.1159/000509217 |