Academic Journal
Successful treatment of CRPS 1 with anti-TNF [4]
| العنوان: | Successful treatment of CRPS 1 with anti-TNF [4] |
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| المؤلفون: | Huygen, Frank J.P.M., Niehof, Sjoerd, Zijlstra, Freek J., Van Hagen, P. Martin, Van Daele, Paul L.A. |
| المصدر: | Huygen , F J P M , Niehof , S , Zijlstra , F J , Van Hagen , P M & Van Daele , P L A 2004 , ' Successful treatment of CRPS 1 with anti-TNF [4] ' , Journal of Pain and Symptom Management , vol. 27 , no. 2 , pp. 101-103 . https://doi.org/10.1016/j.jpainsymman.2003.12.006 |
| سنة النشر: | 2004 |
| الوصف: | To the Editor: Complex regional pain syndrome type 1 (CRPS 1) is a complication that usually occurs in an extremity following surgery or trauma. CRPS 1 is characterized by spontaneous pain, allodynia, and hyperalgesia, is not restricted to the region of a single peripheral nerve, and is often disproportionate to the precipitating injury. Clinical signs include edema, disturbed blood flow to the skin, or abnormal sudomotor activity in the affected limb. The diagnosis of CRPS 1 is excluded by the existence of other conditions that account for the degree of pain and dysfunction. The pathophysiology of CRPS 1 has been ascribed to peripheral afferent, efferent, and central mechanisms, or combinations of all of the above. Consequently, there has been no clear consensus about treatment. CRPS 1 may be resistant to therapeutic strategies used to treat neuropathic pain. The disease itself can be selflimiting, but is often associated with a high morbidity. Recently, we showed evidence of an inflammatory process in CRPS 1 by detecting the presence of cytokines IL-6 and TNFα. As a result of these findings, we concluded that anti-TNF could play a role in the treatment of CRPS 1 and choose to treat 2 CRPS patients with anti-TNF. Biochemical and clinical parameters were monitored as described in our article. Pain was measured using a visual analogue scale, temperature using a local infrared temperature measurement, edema using a volumeter, and motor function by the measurement of active range of motion in the most involved joints. Levels of IL-6 and TNFα were measured in blister fluid drawn from both the affected and unaffected limb using the enzyme-linked immunoassay techniques. [.] |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1016/j.jpainsymman.2003.12.006 |
| الاتاحة: | https://pure.eur.nl/en/publications/52dd239f-71e3-425b-96b5-aba25d73dd00 https://doi.org/10.1016/j.jpainsymman.2003.12.006 https://pure.eur.nl/ws/files/171093796/PIIS0885392403004986.pdf http://www.scopus.com/inward/record.url?scp=1242293157&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.16675C56 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.jpainsymman.2003.12.006 |
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