Academic Journal
Mechanically evoked cortical potentials: A physiological approach to assessment of anorectal sensory pathways
| العنوان: | Mechanically evoked cortical potentials: A physiological approach to assessment of anorectal sensory pathways |
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| المؤلفون: | Carrington, E. V., Evers, Judith, Scott, S. M., Knowles, C. H., O'Connell, P. R., Jones, James F. X. |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2021 |
| المجموعة: | University College Dublin: Research Repository UCD |
| مصطلحات موضوعية: | Intestinal mucosa, Rectum, Somatosensory cortex, Animals, Wistar rats, Equipment design, Physical stimulation, Touch, Somatosensory evoked potentials, Anal, Female, Electrical equipment and supplies, Touch perception, Three-dimensional printing |
| الوصف: | Background: Normal defaecation involves activation of anorectal mechanoreceptors responsive to pressure and stretch. The aim of this study was to develop selective anal and rectal mucosal light-touch stimulation suitable for measurement of cortical evoked potentials (EPs) in order to explore the sensory arm of these pathways. New method: A novel device was manufactured to deliver selective rectal and/or anal light-touch stimulation using a shielded inter-dental brush mounted on a rotating stepper motor (1 Hz, 1 ms, 15° rotation). Resultant somatosensory EPs recorded with a 32-channel cortical multi-electrode array were compared to those elicited by electrical anorectal stimulation (2 mm anal plug electrode [1 Hz, 1 ms, 10 V]). Results: Eighteen anaesthetized female Wistar rats (body mass 180-250 g) were studied. Electrical and mechanical stimulation provoked similar maximal response amplitudes (electrical anorectal 39.0 μV[SEM 5.5], mechanical anal 42.2 μV[8.1], mechanical rectal 45.8 μV[9.0]). Response latency was longer following mechanical stimulation (electrical anorectal 8.8 ms[0.5], mechanical anal 16.4 ms[1.1], mechanical rectal 18.3 ms[2.5]). The extent of activated sensory cortex was smaller for mechanical stimulation. Sensory inferior rectal nerve activity was greater during anal compared to rectal mechanical in a subgroup of 4 rats. Evoked potentials were reproducible over 40 min in a subgroup of 9 rats. Comparison with existing methods: Cortical EPs are typically recorded in response to non-physiological electrical stimuli. The use of a mechanical stimulus may provide a more localized physiological method of assessment. Conclusions: To the authors' knowledge these are the first selective brush-elicited anal and rectal EPs recorded in animals and provide a physiological approach to testing of anorectal afferent pathways. ; Science Foundation Ireland ; Bowel Disease Research Foundation |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | Print-Electronic |
| اللغة: | English |
| تدمد: | 0165-0270 |
| Relation: | Journal of Neuroscience Methods; http://hdl.handle.net/10197/12665; 256; 198; 202; 11/RFP.1/NES/3115 |
| DOI: | 10.1016/j.jneumeth.2015.09.006 |
| الاتاحة: | http://hdl.handle.net/10197/12665 https://doi.org/10.1016/j.jneumeth.2015.09.006 |
| Rights: | This is the author’s version of a work that was accepted for publication in Journal of Neuroscience Methods. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Neuroscience Methods (256, 2015)) https://doi.org/10.1016/j.jneumeth.2015.09.006 ; https://creativecommons.org/licenses/by-nc-nd/3.0/ie/ |
| رقم الانضمام: | edsbas.163059DE |
| قاعدة البيانات: | BASE |
| تدمد: | 01650270 |
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| DOI: | 10.1016/j.jneumeth.2015.09.006 |