Academic Journal
Estrogenic activity of octylphenol, nonylphenol, bisphenol A and methoxychlor in rats. Toxicol
| العنوان: | Estrogenic activity of octylphenol, nonylphenol, bisphenol A and methoxychlor in rats. Toxicol |
|---|---|
| المؤلفون: | Susan C. Laws, Stephan A. Carey, Janet M. Ferrell, Gerald J. Bodman, Ralph L. Cooper |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | http://toxsci.oxfordjournals.org/content/54/1/154.full.pdf. |
| سنة النشر: | 2000 |
| المجموعة: | CiteSeerX |
| الوصف: | Considerable attention has recently been focused on environmental chemicals that disrupt the reproductive system by altering steroid receptor function. Although numerous in vitro and in vivo methods have been shown to be useful approaches for identifying chemicals that can disrupt reproduction through a direct interaction with the estrogen receptor, it is imperative that the protocols selected be capable of detecting chemicals with a broad range of estrogenic activity. Here we evaluate the reliability of the 3-day uterotrophic assay for detecting chemicals with strong or weak estrogenic activity in both prepubertal and ovariectomized adult Long Evans rats. These data were compared to additional measures of estrogenic activity, which included the age of vaginal opening, the induction of cornified vaginal epithelial cells in ovariectomized adult rats, and estrous cyclicity in intact adult rats. Test chemicals selected for these studies included 17-�-estradiol, ethynyl |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.335.4973; http://toxsci.oxfordjournals.org/content/54/1/154.full.pdf |
| الاتاحة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.335.4973 http://toxsci.oxfordjournals.org/content/54/1/154.full.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.16150F8E |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |