Academic Journal
Primula vulgaris extract induces cell cycle arrest and apoptosis in human cervix cancer cells
| العنوان: | Primula vulgaris extract induces cell cycle arrest and apoptosis in human cervix cancer cells |
|---|---|
| المؤلفون: | Demir, Selim, Turan, Ibrahim, Aliyazicioglu, Rezzan, Yaman, Serap Ozer, Aliyazicioglu, Yuksel |
| بيانات النشر: | Elsevier Science Bv |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Apoptosis, Cell cycle, Cervical cancer, Cytotoxicity, Primula vulgaris |
| الوصف: | Primula vulgaris belongs to the genus Primula, members of which are frequently used in folk medicine. Various studies have investigated the cytotoxic effect of different Primula species, but there have been limited studies on the cytotoxic effect of P. vulgaris. The aim of this study was to investigate the cytotoxic effects, and possible mechanisms involved, of P. vulgaris flower extract on human cervical cancer (HeLa) cells. The cytotoxic effect of the extract on HeLa cells was revealed using the MTT assay. Mechanisms involved in the extract's cytotoxic effect were then investigated in terms of apoptosis, mitochondrial membrane potential, and the cell cycle, using fluorometric methods. P. vulgaris flower extract exhibited selective cytotoxic effects against HeLa cells by arresting their cell cycle at the S phase, and inducing the number of apoptotic cells compared to normal fibroblast cells by reducing mitochondrial membrane potential in a concentration-dependent manner. This is the first study to reveal the antiproliferative effect of P. vulgaris flower extract. Further studies are now needed to identify the cytotoxic molecules in the extract and their mechanisms. (C) 2018 Xi'an Jiaotong University. Production and hosting by Elsevier B.V. ; WOS:000447188200004 ; 2-s2.0-85049001497 ; PubMed: 30345144 |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2095-1779 2214-0883 |
| Relation: | Journal of Pharmaceutical Analysis; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.1016/j.jpha.2018.05.003; https://hdl.handle.net/20.500.12440/3552; 307; 311 |
| DOI: | 10.1016/j.jpha.2018.05.003 |
| الاتاحة: | https://hdl.handle.net/20.500.12440/3552 https://doi.org/10.1016/j.jpha.2018.05.003 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.15E9881A |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20951779 22140883 |
|---|---|
| DOI: | 10.1016/j.jpha.2018.05.003 |