Academic Journal
Impact of post-transplant cyclophosphamide (PTCy)-based prophylaxis in matched sibling donor allogeneic haematopoietic cell transplantation for patients with myelodysplastic syndrome: a retrospective study on behalf of the Chronic Malignancies Working Party of the EBMT
| العنوان: | Impact of post-transplant cyclophosphamide (PTCy)-based prophylaxis in matched sibling donor allogeneic haematopoietic cell transplantation for patients with myelodysplastic syndrome: a retrospective study on behalf of the Chronic Malignancies Working Party of the EBMT |
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| المؤلفون: | Salas, María Queralt, Eikema, Diderik-Jan, Koster, Linda, Maertens, Johan, Passweg, Jakob, Finke, Jürgen, Broers, Annoek E. C., Koc, Yener, Kröger, Nicolaus, Ozkurt, Zubeyde Nur, Pascual-Cascon, María Jesús, Platzbecker, Uwe, Van Gorkom, Gwendolyn, Schroeder, Thomas, López-Lorenzo, José Luis, Martino, Massimo, Chiusolo, Patrizia, Kaufmann, Martin, Onida, Francesco, Gurnari, Carmelo, Scheid, Christof, Drozd-Sokolowska, Joanna, Raj, Kavita, Robin, Marie, McLornan, Donal P. |
| المساهمون: | M.Q. Sala, D. Eikema, L. Koster, J. Maerten, J. Passweg, J. Finke, A.E.C. Broer, Y. Koc, N. Kröger, Z.N. Ozkurt, M.J. Pascual-Cascon, U. Platzbecker, G. Van Gorkom, T. Schroeder, J.L. López-Lorenzo, M. Martino, P. Chiusolo, M. Kaufmann, F. Onida, C. Gurnari, C. Scheid, J. Drozd-Sokolowska, K. Raj, M. Robin, D.P. Mclornan |
| بيانات النشر: | Springer |
| سنة النشر: | 2024 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | Settore MED/15 - Malattie del Sangue, Settore MED/06 - Oncologia Medica |
| الوصف: | We retrospectively compared outcomes of 404 MDS patients undergoing 1st matched sibling donor allo-HCT receiving either PTCy-based (n = 66) or other "conventional prophylaxis" (n = 338; mostly calcineurin inhibitor + methotrexate or MMF). Baseline characteristics were balanced, except for higher use of myeloablative regimens in the PTCy group (52.3% vs. 38.2%, p = 0.047). Incidences of neutrophil (Day +28: 89% vs. 97%, p = 0.011) and platelet (Day +100: 89% vs. 97%, p < 0.001) engraftment were lower for PTCy-based. Day +100 cumulative incidences of grade II-IV and III-IV aGVHD, and 5-year CI of extensive cGVHD were 32%, 18% and 18% for PTCy-based and 25% (p = 0.3), 13% (p = 0.4) and 31% (p = 0.09) for the conventional cohort. Five-year OS (51% vs. 52%, p = 0.6) and GRFS (33% vs. 25%, p = 0.6) were similar between groups. Patients receiving PTCy had a trend to a lower cumulative incidence of relapse (20% vs. 33%, p = 0.06), not confirmed on multivariable analysis (p = 0.3). Although higher NRM rates were observed in patients receiving PTCy (32% vs. 21%, p = 0.02) on univariate analysis, this was not confirmed on multivariate analysis (HR 1.46, p = 0.18), and there was no resultant effect on OS (HR 1.20, p = 0.5). Based on these data, PTCy prophylaxis appears to be an attractive option for patients with MDS undergoing MSD allo-HCT. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/38253869; info:eu-repo/semantics/altIdentifier/wos/WOS:001154985200001; volume:59; issue:4; firstpage:479; lastpage:488; numberofpages:10; journal:BONE MARROW TRANSPLANTATION; https://hdl.handle.net/2434/1042870; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85182856628 |
| DOI: | 10.1038/s41409-023-02159-1 |
| الاتاحة: | https://hdl.handle.net/2434/1042870 https://doi.org/10.1038/s41409-023-02159-1 |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.15D1F213 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41409-023-02159-1 |
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