Academic Journal
Time Course of Dopamine‐D 2 and Serotonin‐5‐HT 2 Receptor Occupancy Rates by Haloperidol and Clozapine In Vivo
| العنوان: | Time Course of Dopamine‐D 2 and Serotonin‐5‐HT 2 Receptor Occupancy Rates by Haloperidol and Clozapine In Vivo |
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| المؤلفون: | Sumiyoshi, Tomiki, Kido, Hideki, Sakamoto, Hiroshi, Urasaki, Koji, Suzuki, Kimiko, Yamaguchi, Nariyoshi, Mori, Hirofumi, Shiba, Kazuhiro, Yokogawa, Koiçhi, Ichimura, Fujio |
| المصدر: | Psychiatry and Clinical Neurosciences ; volume 47, issue 1, page 131-137 ; ISSN 1323-1316 1440-1819 |
| بيانات النشر: | Wiley |
| سنة النشر: | 1993 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | In vivo occupancy of dopamine‐D 1 , D 2 and serotonin‐5‐HT 2 receptors by haloperidol 10 mg/kg and clozapine 20 mg/kg were studied. Rats were injected intravenously with [ 3 H]‐YM‐09151‐2, [ 3 H]‐SCH23390, or [ 3 H]‐ketanserin 10 min after the administration of the tested drugs. Fifteen to 240 min after the ligand injection, the receptor occupancy rates of the drugs in the striatum and frontal cortex were calculated. Clozapine demonstrated the higher 5‐HT 2 and lower D 2 occupancies in the respective regions. A dose‐response analysis of D 2 and 5‐HT 2 , receptor occupancy by the drugs consolidated the higher 5‐HT 2 binding affinity of clozapine in comparison with haloperidol. The present methodology may serve as an accurate tool to evaluate the peculiarity of various antipsychotics. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/j.1440-1819.1993.tb02041.x |
| الاتاحة: | http://dx.doi.org/10.1111/j.1440-1819.1993.tb02041.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1440-1819.1993.tb02041.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1440-1819.1993.tb02041.x |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.15C340AC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/j.1440-1819.1993.tb02041.x |
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