Academic Journal
Increased ERK signalling promotes inflammatory signalling in primary airway epithelial cells expressing Z {alpha}1-antitrypsin
| العنوان: | Increased ERK signalling promotes inflammatory signalling in primary airway epithelial cells expressing Z {alpha}1-antitrypsin |
|---|---|
| المؤلفون: | van t Wout, Emily F.A., Dickens, Jennifer A., van Schadewijk, Annemarie, Haq, Imran, Kwok, Hang Fai, Ordóñez, Adriana, Murphy, Gillian, Stolk, Jan, Lomas, David A., Hiemstra, Pieter S., Marciniak, Stefan J. |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2014 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | ARTICLES |
| الوصف: | Overexpression of Z α 1 -antitrypsin is known to induce polymer formation, prime the cells for endoplasmic reticulum stress and initiate nuclear factor kappa B (NF-κB) signalling. However, whether endogenous expression in primary bronchial epithelial cells has similar consequences remains unclear. Moreover, the mechanism of NF-κB activation has not yet been elucidated. Here, we report excessive NF-κB signalling in resting primary bronchial epithelial cells from ZZ patients compared with wild-type (MM) controls, and this appears to be mediated by mitogen-activated protein/extracellular signal-regulated kinase, EGF receptor and ADAM17 activity. Moreover, we show that rather than being a response to protein polymers, NF-κB signalling in airway-derived cells represents a loss of anti-inflammatory signalling by M α 1 -antitrypsin. Treatment of ZZ primary bronchial epithelial cells with purified plasma M α 1 -antitrypsin attenuates this inflammatory response, opening up new therapeutic options to modulate airway inflammation in the lung. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| Relation: | http://hmg.oxfordjournals.org/cgi/content/short/23/4/929; http://dx.doi.org/10.1093/hmg/ddt487 |
| DOI: | 10.1093/hmg/ddt487 |
| الاتاحة: | http://hmg.oxfordjournals.org/cgi/content/short/23/4/929 https://doi.org/10.1093/hmg/ddt487 |
| Rights: | Copyright (C) 2014, Oxford University Press |
| رقم الانضمام: | edsbas.15AAD485 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/hmg/ddt487 |
|---|