Academic Journal
Follicle-stimulating hormone in postmenopausal women living with HIV: a prevalence study
| العنوان: | Follicle-stimulating hormone in postmenopausal women living with HIV: a prevalence study |
|---|---|
| المؤلفون: | Tariq, S, Okhai, H, Severn, A, Sabin, CA, Burns, F, Gilson, R, Fox, J, Gilleece, Y, Mackie, NE, Post, FA, Reeves, I, Rosenvinge, M, Sullivan, A, Ustianowski, A, Miller, RF |
| المصدر: | HIV Medicine , 23 (4) pp. 434-440. (2022) |
| سنة النشر: | 2022 |
| المجموعة: | University College London: UCL Discovery |
| مصطلحات موضوعية: | HIV, ageing, follicle-stimulating hormone, menopause, women |
| الوصف: | OBJECTIVES: We examined follicle-stimulating hormone (FSH) levels in women living with HIV aged > 45 reporting ≥ 12 months' amenorrhoea, and investigated correlation with menopausal symptoms. METHODS: A cross-sectional substudy of 85 women from the Positive Transitions through the Menopause (PRIME) Study who reported irregular periods at entry into the PRIME Study and ≥ 12 months' amenorrhoea at recruitment into this substudy. Serum FSH was supplemented with clinical data and menopausal symptom assessment. Serum FSH > 30 mIU/mL was defined as consistent with postmenopausal status. Associations between FSH and menopausal symptom severity were assessed using Pearson's correlation and the Kruskal-Wallis test. RESULTS: Median age was 53 years [interquartile range (IQR): 51-55]; all were on antiretroviral therapy, three-quarters (n = 65) had a CD4 T-cell count > 500 cells/μL and 91.8% (n = 78) had an HIV viral load (VL) < 50 copies/mL. Median FSH was 65.9 mIU/mL (IQR: 49.1-78.6). Only four women (4.7%) had FSH ≤ 30 mIU/mL; none reported smoking or drug use, all had CD4 T-cell count ≥ 200 cells/μL, and one had viral load (VL) ≥ 50 copies/mL. Median body mass index (BMI) was elevated compared with women with FSH > 30 mIU/mL (40.8 vs. 30.5 kg/m2 ). Over a quarter (28.2%) reported severe menopausal symptoms, with no correlation between FSH and severity of menopausal symptoms (p = 0.21), or hot flushes (p = 0.37). CONCLUSIONS: Four women in this small substudy had low FSH despite being amenorrhoeic; all had BMI ≥ 35 kg/m2 . We found that 95% of women with HIV aged > 45 years reporting ≥ 12 months' amenorrhoea had elevated FSH, suggesting that menopausal status can be ascertained from menstrual history alone in this group. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| Relation: | https://discovery.ucl.ac.uk/id/eprint/10138955/1/Miller_hiv.13205.pdf; https://discovery.ucl.ac.uk/id/eprint/10138955/ |
| الاتاحة: | https://discovery.ucl.ac.uk/id/eprint/10138955/1/Miller_hiv.13205.pdf https://discovery.ucl.ac.uk/id/eprint/10138955/ |
| Rights: | open |
| رقم الانضمام: | edsbas.15590D74 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |