Academic Journal
Different rates of cognitive decline in autosomal dominant and late-onset Alzheimer disease
| العنوان: | Different rates of cognitive decline in autosomal dominant and late-onset Alzheimer disease |
|---|---|
| المؤلفون: | Buckles, VD, Xiong, C, Bateman, RJ, Hassenstab, J, Allegri, R, Berman, SB, Chhatwal, JP, Danek, A, Fagan, AM, Ghetti, B, Goate, A, Graff-Radford, N, Jucker, M, Levin, J, Marcus, DS, Masters, CL, McCue, L, McDade, E, Mori, H, Moulder, KL, Noble, JM, Paumier, K, Preische, O, Ringman, JM, Fox, NC, Salloway, S, Schofield, PR, Martins, R, Vöglein, J, Morris, JC, Dominantly Inherited Alzheimer's Network |
| المصدر: | Alzheimer's & Dementia , 18 (10) pp. 1754-1764. (2022) |
| سنة النشر: | 2022 |
| المجموعة: | University College London: UCL Discovery |
| مصطلحات موضوعية: | Alzheimer disease, autosomal dominant Alzheimer disease, cognitive, comorbidities, late-onset Alzheimer disease |
| الوصف: | As prevention trials advance with autosomal dominant Alzheimer disease (ADAD) participants, understanding the similarities and differences between ADAD and "sporadic" late-onset AD (LOAD) is critical to determine generalizability of findings between these cohorts. Cognitive trajectories of ADAD mutation carriers (MCs) and autopsy-confirmed LOAD individuals were compared to address this question. Longitudinal rates of change on cognitive measures were compared in ADAD MCs (n = 310) and autopsy-confirmed LOAD participants (n = 163) before and after symptom onset (estimated/observed). LOAD participants declined more rapidly in the presymptomatic (preclinical) period and performed more poorly at symptom onset than ADAD participants on a cognitive composite. After symptom onset, however, the younger ADAD MCs declined more rapidly. The similar but not identical cognitive trajectories (declining but at different rates) for ADAD and LOAD suggest common AD pathologies but with some differences. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| Relation: | https://discovery.ucl.ac.uk/id/eprint/10141384/3/Fox_DIAN-NACC%20comparison%201-4-22%20with%20figures.pdf; https://discovery.ucl.ac.uk/id/eprint/10141384/ |
| الاتاحة: | https://discovery.ucl.ac.uk/id/eprint/10141384/3/Fox_DIAN-NACC%20comparison%201-4-22%20with%20figures.pdf https://discovery.ucl.ac.uk/id/eprint/10141384/ |
| Rights: | open |
| رقم الانضمام: | edsbas.154F55E3 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |