Academic Journal
Amphiphilic Sialic Acid Derivatives as Potential Dual-Specific Inhibitors of Influenza Hemagglutinin and Neuraminidase
| العنوان: | Amphiphilic Sialic Acid Derivatives as Potential Dual-Specific Inhibitors of Influenza Hemagglutinin and Neuraminidase |
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| المؤلفون: | Eszter Boglárka Lőrincz, Mihály Herczeg, Josef Houser, Martina Rievajová, Ákos Kuki, Lenka Malinovská, Lieve Naesens, Michaela Wimmerová, Anikó Borbás, Pál Herczegh, Ilona Bereczki |
| المصدر: | International Journal of Molecular Sciences, Vol 24, Iss 24, p 17268 (2023) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2023 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | influenza, sialic acid, neuraminidase, hemagglutinin, aggregates, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | In the shadow of SARS-CoV-2, influenza seems to be an innocent virus, although new zoonotic influenza viruses evolved by mutations may lead to severe pandemics. According to WHO, there is an urgent need for better antiviral drugs. Blocking viral hemagglutinin with multivalent N -acetylneuraminic acid derivatives is a promising approach to prevent influenza infection. Moreover, dual inhibition of both hemagglutinin and neuraminidase may result in a more powerful effect. Since both viral glycoproteins can bind to neuraminic acid, we have prepared three series of amphiphilic self-assembling 2-thio-neuraminic acid derivatives constituting aggregates in aqueous medium to take advantage of their multivalent effect. One of the series was prepared by the azide-alkyne click reaction, and the other two by the thio-click reaction to yield neuraminic acid derivatives containing lipophilic tails of different sizes and an enzymatically stable thioglycosidic bond. Two of the three bis-octyl derivatives produced proved to be active against influenza viruses, while all three octyl derivatives bound to hemagglutinin and neuraminidase from H1N1 and H3N2 influenza types. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/24/24/17268; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067; https://doaj.org/article/ab384dde763d4113b4a3247c043b338d |
| DOI: | 10.3390/ijms242417268 |
| الاتاحة: | https://doi.org/10.3390/ijms242417268 https://doaj.org/article/ab384dde763d4113b4a3247c043b338d |
| رقم الانضمام: | edsbas.154D0198 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms242417268 |