Academic Journal
Quantification of bone microarchitecture using photon-counting CT at different radiation doses:A comparison with µCT
| العنوان: | Quantification of bone microarchitecture using photon-counting CT at different radiation doses:A comparison with µCT |
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| المؤلفون: | Kok, Joeri, Bevers, Melissa S.A.M., van Rietbergen, Bert, Oei, Edwin H.G., Booij, Ronald |
| المصدر: | Kok , J , Bevers , M S A M , van Rietbergen , B , Oei , E H G & Booij , R 2024 , ' Quantification of bone microarchitecture using photon-counting CT at different radiation doses : A comparison with µCT ' , European Journal of Radiology , vol. 181 , 111717 . https://doi.org/10.1016/j.ejrad.2024.111717 |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Computed tomography, Image quality, Musculoskeletal system, Photon-counting detector CT |
| الوصف: | PURPOSE: Accurate measurements of trabecular bone microarchitecture are required for a proper assessment of bone fragility. Photon-counting detector CT (PCD-CT) has different technical properties than conventional CT, resulting in higher resolution and thereby potentially enabling in-vivo measurement of trabecular microarchitecture. The purpose of this study was to quantify trabecular bone microarchitectural parameters with PCD-CT at varying radiation doses and compare this to µCT as gold standard. METHOD: Both distal radii, distal tibiae, femoral heads, and two vertebrae were dissected from one human. All specimens were scanned ex-vivo on a PCD-CT system (slice increment 0.1 mm; pixel size 0.1042-0.127 mm) and a µCT system (isotropic voxel size 49-68.4 µm). The radiation doses of the PCD-CT scans were varied from 2.5 to 120 mGy based on the volume CT dose index (CTDI vol32). For the PCD-CT scans, contrast-to-noise ratio and trabecular sharpness were calculated and compared between radiation doses. µCT and PCD-CT scans were registered. The trabecular bone was then segmented from all PCD-CT and µCT scans and split into cubes with 6-mm edge length. For each cube, bone volume over total volume, trabecular thickness, trabecular number, and trabecular heterogeneity were calculated and compared between corresponding PCD-CT and µCT cubes. RESULTS: With increasing dose, contrast-to-noise ratio and trabecular sharpness values increased for the PCD-CT images. Already at the lowest dose, high correlations between the trabecular microarchitectural parameters between µCT and PCD-CT were found (R 2 = 0.55-0.95), which improved with increasing radiation dose (R 2 = 0.76-0.96 at 20 mGy). CONCLUSIONS: PCD-CT can be used to quantify trabecular bone microarchitecture, with accuracy comparable to µCT and at clinically relevant radiation doses. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1016/j.ejrad.2024.111717 |
| الاتاحة: | https://research.tue.nl/en/publications/3d76b492-a58b-410d-89b0-3fd7fb929300 https://doi.org/10.1016/j.ejrad.2024.111717 https://pure.tue.nl/ws/files/340229793/1-s2.0-S0720048X24004339-main.pdf http://www.scopus.com/inward/record.url?scp=85203194055&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.150A7066 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.ejrad.2024.111717 |
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