التفاصيل البيبلوغرافية
| العنوان: |
PDT-Enhanced Ferroptosis by a Polymer Nanoparticle with pH-Activated Singlet Oxygen Generation and Superb Biocompatibility for Cancer Therapy |
| المؤلفون: |
Jing Li (10611), Junhua Li (125998), Yuji Pu (2281027), Sai Li (307025), Wenxia Gao (1515058), Bin He (75597) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biochemistry, Medicine, Microbiology, Neuroscience, Pharmacology, Immunology, Cancer, Computational Biology, Space Science, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, TAPP, pH-Activated Singlet Oxygen Generation, PAF, B 16 melanoma cells, PEGylated polygalacturonic acid, intracellular reactive oxygen speci., polysaccharide-based polymer carrier, Fe, 1 O 2, 1 O 2 generation capability, PDT-enhanced ferroptosis |
| الوصف: |
In this study, we reported a nanocomplex (PAF) of PEGylated polygalacturonic acid, 5,10,15,20-tetrakis (4-aminophenyl) porphyrin (TAPP), and Fe 3+ for photodynamic therapy (PDT)-enhanced ferroptosis in cancer treatment. PAF exhibited a size of 135 nm and a TAPP and Fe 3+ loading content of 6.99 and 0.77%, respectively. The singlet oxygen ( 1 O 2 ) generation capacity of TAPP can be activated and significantly enhanced at acidic pH (4.5–5.0). Besides, the enhanced near-infrared absorption of TAPP at acidic pH enabled a further increase in 1 O 2 generation capability by a near-infrared laser (760 nm). The polysaccharide-based polymer carrier offers excellent biocompatibility, and PAF displayed a proliferative effect in both normal (L929) and cancer (B16) cells. However, upon light irradiation, PAF exhibited high toxicity to B16 melanoma cells by intracellular reactive oxygen species elevation, glutathione depletion, and lipid peroxidation. PAF displayed a much better anticancer effect than the nanocomplex containing Fe 3+ or TAPP alone, indicating the PDT-enhanced ferroptosis in PAF. This study suggested that PDT-enhanced ferroptosis could be a facile and robust strategy of nanotherapeutics with high potency, tumor selectivity, and excellent biocompatibility. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/journal_contribution/PDT-Enhanced_Ferroptosis_by_a_Polymer_Nanoparticle_with_pH-Activated_Singlet_Oxygen_Generation_and_Superb_Biocompatibility_for_Cancer_Therapy/13863912 |
| DOI: |
10.1021/acs.biomac.0c01679.s001 |
| الاتاحة: |
https://doi.org/10.1021/acs.biomac.0c01679.s001 |
| Rights: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.149A2B1A |
| قاعدة البيانات: |
BASE |