Academic Journal
Prostate Volume and Its Correlation with Histopathological Outcomes in Prostate Cancer
| العنوان: | Prostate Volume and Its Correlation with Histopathological Outcomes in Prostate Cancer |
|---|---|
| المؤلفون: | Sooriakumaran, Prasanna, Srivastava, Abhishek, Bhagat, Dhristie, John, Majnu, Grover, Sonal, El-Douaihy, Youssef, Rajan, Sivaram, Leung, Robert, Tewari, Ashutosh |
| المصدر: | Urologia Internationalis ; volume 86, issue 2, page 152-155 ; ISSN 0042-1138 1423-0399 |
| بيانات النشر: | S. Karger AG |
| سنة النشر: | 2011 |
| الوصف: | Introduction: There is a paucity of data investigating the relationship between histopathological variables of oncologic importance and prostate volume, and we aimed to investigate this. Patients and Methods: 2,207 consecutive patients who underwent robotic-assisted radical prostatectomy were studied. Preoperative demographic and both pre- and postoperative histopathological parameters were compared among the small (<40 cm 3 ), intermediate (40–70 cm 3 ), and large (>70 cm 3 ) prostate groups. Results: Patients with smaller prostates were younger, had slightly lower BMIs, and lower prostate-specific antigen (PSA) levels than those with larger prostates (p < 0.001). They also had worse histopathological criteria (Gleason, core positivity, and maximum percent cancer) on preoperative biopsy and had worse radical specimen Gleason sums (p < 0.001), percent cancer (p < 0.001), and pathological stage (p = 0.016). 11.5% of the men in the small prostate group suffered a positive surgical margin (PSM) compared to 8.3 and 5.6% in the intermediate and large prostate groups, respectively (p = 0.008). Basilar, posterolateral, and multifocal PSMs were commoner in the small prostate group. Conclusions: Younger men have smaller prostates and worse preoperative histopathological parameters despite lower PSA values. Men with small prostates undergoing robotic-assisted radical prostatectomy have worse final Gleason sums, tumour volume, extraprostatic extension, and PSM rates than those with larger prostates. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1159/000322361 |
| الاتاحة: | http://dx.doi.org/10.1159/000322361 https://www.karger.com/Article/Pdf/322361 |
| Rights: | https://www.karger.com/Services/SiteLicenses ; https://www.karger.com/Services/SiteLicenses |
| رقم الانضمام: | edsbas.1449B961 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1159/000322361 |
|---|