Academic Journal
Effect of Resistant Dextrin on Intestinal Gas Homeostasis and Microbiota
| العنوان: | Effect of Resistant Dextrin on Intestinal Gas Homeostasis and Microbiota |
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| المؤلفون: | Ávila-Gálvez, María Ángeles, Vallejo, Fernando, Bendezú García, Rogger Alvaro, Guérin-Deremaux, Laetitia, Guarner Aguilar, Fernando, Espín, Juan Carlos, Margolles, A, Azpiroz Vidaur, Fernando, Barber Caselles, Claudia, Sabater, Carlos |
| المساهمون: | Institut Català de la Salut, Barber C, Azpiroz F Servei d’Aparell Digestiu, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Ciberehd), Madrid, Spain. Sabater C, Margolles A Department of Microbiology and Biochemistry, IPLA-CSIC, Asturias, Spain. Health Research Institute of Asturias, ISPA, Asturias, Spain. Ávila-Gálvez MÁ, Espín JC Laboratory of Food & Health, Group of Quality, Safety, and Bioactivity of Plant Foods, CEBAS-CSIC, Murcia, Spain. Vallejo F Metabolomics Service, CEBAS-CSIC, Campus de Espinardo, Murcia, Spain. Bendezu RA Hospital General de Cataluña, Barcelona, Spain. Guérin-Deremaux L Roquette Frères, Lestrem, France. Guarner F Servei d’Aparell Digestiu, Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus |
| المصدر: | Scientia |
| بيانات النشر: | MDPI |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Intestins - Microbiologia, Prebiòtics, Homeòstasi, Aparell digestiu - Fisiologia patològica, PHENOMENA AND PROCESSES::Microbiological Phenomena::Microbiota, PHENOMENA AND PROCESSES::Physiological Phenomena::Homeostasis, PHENOMENA AND PROCESSES::Physiological Phenomena::Diet, Food, and Nutrition::Food::Dietary Fiber::Physiological Phenomena::Diet, and Nutrition::Food::Prebiotics, PHENOMENA AND PROCESSES::Digestive System and Oral Physiological Phenomena::Digestive System Physiological Phenomena, FENÓMENOS Y PROCESOS::fenómenos microbiológicos::microbiota, FENÓMENOS Y PROCESOS::fenómenos fisiológicos::homeostasis, FENÓMENOS Y PROCESOS::fenómenos fisiológicos::dieta, alimentación y nutrición::alimentos::fibras de la dieta::fenómenos fisiológicos::dieta, alimentación y nutrición::alimentos::prebióticos, FENÓMENOS Y PROCESOS::fenómenos fisiológicos orales y del sistema digestivo::fenómenos fisiológicos del sistema digestivo |
| الوصف: | Gut microbiota; Intestinal gas; Resistant dextrin ; Microbiota intestinal; Gases intestinales; Dextrina resistente ; Microbiota intestinal; Gas intestinal; Dextrina resistent ; Previous studies have shown that a resistant dextrin soluble fibre has prebiotic properties with related health benefits on blood glucose management and satiety. Our aim was to demonstrate the effects of continuous administration of resistant dextrin on intestinal gas production, digestive sensations, and gut microbiota metabolism and composition. Healthy subjects (n = 20) were given resistant dextrin (14 g/d NUTRIOSE®, Roquette Frères, Lestrem, France) for four weeks. Outcomes were measured before, at the beginning, end, and two weeks after administration: anal evacuations of gas during daytime; digestive perception, girth, and gas production in response to a standard meal; sensory and digestive responses to a comfort meal; volume of colonic biomass by magnetic resonance; taxonomy and metabolic functions of fecal microbiota by shotgun sequencing; metabolomics in urine. Dextrin administration produced an initial increase in intestinal gas production and gas-related sensations, followed by a subsequent decrease, which magnified after discontinuation. Dextrin enlarged the volume of colonic biomass, inducing changes in microbial metabolism and composition with an increase in short chain fatty acids-producing species and modulation of bile acids and biotin metabolism. These data indicate that consumption of a soluble fibre induces an adaptative response of gut microbiota towards fermentative pathways with lower gas production. ; This work was supported by a grant from Roquette. The research activities were supported in part by the projects PID2021-122295OB-I00 (Ministerio de Ciencia e Innovación, Spain), PID2019-103914RB-I00 (Ministerio de Ciencia e Innovación, Spain), AGL2016-78311-R (Ministerio de Ciencia e Innovación, Spain) and FJC2019-042125-I (Ministerio de Ciencia e Innovación, Spain). Ciberehd is funded by the Instituto de Salud ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2072-6643 |
| Relation: | Nutrients;14(21); https://doi.org/10.3390/nu14214611; info:eu-repo/grantAgreement/ES/PEICTI2021-2023/PID2021-122295OB-I00; Barber C, Sabater C, Ávila-Gálvez MÁ, Vallejo F, Bendezu RA, Guérin-Deremaux L, et al. Effect of Resistant Dextrin on Intestinal Gas Homeostasis and Microbiota. Nutrients. 2022 Nov 2;14(21):4611.; https://hdl.handle.net/11351/8562; 000883601200001 |
| DOI: | 10.3390/nu14214611 |
| الاتاحة: | https://hdl.handle.net/11351/8562 https://doi.org/10.3390/nu14214611 |
| Rights: | Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.142797C2 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20726643 |
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| DOI: | 10.3390/nu14214611 |