Academic Journal
Detection and Characterization of Clade 1 Reassortant H5N1 Viruses Isolated from Human Cases in Vietnam during 2013.
| العنوان: | Detection and Characterization of Clade 1 Reassortant H5N1 Viruses Isolated from Human Cases in Vietnam during 2013. |
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| المؤلفون: | Sharmi W Thor, Hieu Nguyen, Amanda Balish, Anh Nguyen Hoang, Kortney M Gustin, Pham Thi Nhung, Joyce Jones, Ngoc Nguyen Thu, William Davis, Thao Nguyen Thi Ngoc, Yunho Jang, Katrina Sleeman, Julie Villanueva, James Kile, Larisa V Gubareva, Stephen Lindstrom, Terrence M Tumpey, C Todd Davis, Nguyen Thanh Long |
| المصدر: | PLoS ONE, Vol 10, Iss 8, p e0133867 (2015) |
| بيانات النشر: | Public Library of Science (PLoS) |
| سنة النشر: | 2015 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Highly pathogenic avian influenza (HPAI) H5N1 is endemic in Vietnamese poultry and has caused sporadic human infection in Vietnam since 2003. Human infections with HPAI H5N1 are of concern due to a high mortality rate and the potential for the emergence of pandemic viruses with sustained human-to-human transmission. Viruses isolated from humans in southern Vietnam have been classified as clade 1 with a single genome constellation (VN3) since their earliest detection in 2003. This is consistent with detection of this clade/genotype in poultry viruses endemic to the Mekong River Delta and surrounding regions. Comparison of H5N1 viruses detected in humans from southern Vietnamese provinces during 2012 and 2013 revealed the emergence of a 2013 reassortant virus with clade 1.1.2 hemagglutinin (HA) and neuraminidase (NA) surface protein genes but internal genes derived from clade 2.3.2.1a viruses (A/Hubei/1/2010-like; VN12). Closer analysis revealed mutations in multiple genes of this novel genotype (referred to as VN49) previously associated with increased virulence in animal models and other markers of adaptation to mammalian hosts. Despite the changes identified between the 2012 and 2013 genotypes analyzed, their virulence in a ferret model was similar. Antigenically, the 2013 viruses were less cross-reactive with ferret antiserum produced to the clade 1 progenitor virus, A/Vietnam/1203/2004, but reacted with antiserum produced against a new clade 1.1.2 WHO candidate vaccine virus (A/Cambodia/W0526301/2012) with comparable hemagglutination inhibition titers as the homologous antigen. Together, these results indicate changes to both surface and internal protein genes of H5N1 viruses circulating in southern Vietnam compared to 2012 and earlier viruses. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | http://europepmc.org/articles/PMC4526568?pdf=render; https://doaj.org/toc/1932-6203; https://doaj.org/article/9d16ddcf2da84c269e6f885fb2dc1a53 |
| DOI: | 10.1371/journal.pone.0133867 |
| الاتاحة: | https://doi.org/10.1371/journal.pone.0133867 https://doaj.org/article/9d16ddcf2da84c269e6f885fb2dc1a53 |
| رقم الانضمام: | edsbas.141F3176 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0133867 |