التفاصيل البيبلوغرافية
| العنوان: |
Image_1_Rational Design of Hyaluronic Acid-Based Copolymer-Mixed Micelle in Combination PD-L1 Immune Checkpoint Blockade for Enhanced Chemo-Immunotherapy of Melanoma.pdf |
| المؤلفون: |
Chaopei Zhou (6728486), Xiuxiu Dong (5080304), Chunxiang Song (10279361), Shuang Cui (2428774), Tiantian Chen (1655986), Daji Zhang (10279364), Xiuli Zhao (1567936), Chunrong Yang (294274) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biotechnology, Biological Engineering, Genetic Engineering, Biomarkers, Biomaterials, Biomechanical Engineering, Biomedical Engineering not elsewhere classified, Synthetic Biology, Agricultural Marine Biotechnology, Bioremediation, Bioprocessing, Bioproduction and Bioproducts, Industrial Biotechnology Diagnostics (incl. Biosensors), Industrial Microbiology (incl. Biofeedstocks), Industrial Molecular Engineering of Nucleic Acids and Proteins, Industrial Biotechnology not elsewhere classified, Medical Biotechnology Diagnostics (incl. Biosensors), Medical Molecular Engineering of Nucleic Acids and Proteins, Regenerative Medicine (incl. Stem Cells and Tissue Engineering), Medical Biotechnology not elsewhere classified, hyaluronic acid, mixed micelle, chemo-immunotherapy combinations, drug delivery system, programmed cell death ligand 1 (PD-L1) |
| الوصف: |
The application of combinational therapy breaks the limitation of monotherapy and achieves better clinical benefit for tumor therapy. Herein, a hyaluronic acid/Pluronic F68-based copolymer-mixed micelle was constructed for targeted delivery of chemotherapeutical agent docetaxel (PHDM) in combination with programmed cell death ligand-1(PD-L1) antibody. When PHDM+anti-PDL1 was injected into the blood system, PHDM could accumulate into tumor sites and target tumor cells via CD44-mediated endocytosis and possess tumor chemotherapy. While anti-PDL1 could target PD-L1 protein expressed on surface of tumor cells to the immune checkpoint blockade characteristic for tumor immunotherapy. This strategy could not only directly kill tumor cells but also improve CD8 + T cell level and facilitate effector cytokines release. In conclusion, the rational-designed PHDM+anti-PDL1 therapy strategy creates a new way for tumor immune-chemotherapy. |
| نوع الوثيقة: |
still image |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/figure/Image_1_Rational_Design_of_Hyaluronic_Acid-Based_Copolymer-Mixed_Micelle_in_Combination_PD-L1_Immune_Checkpoint_Blockade_for_Enhanced_Chemo-Immunotherapy_of_Melanoma_pdf/14190446 |
| DOI: |
10.3389/fbioe.2021.653417.s001 |
| الاتاحة: |
https://doi.org/10.3389/fbioe.2021.653417.s001 |
| Rights: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.1415DF6C |
| قاعدة البيانات: |
BASE |