Academic Journal
EFFECT OF HYDROGEN SULPHIDE ON β‐AMYLOID‐INDUCED DAMAGE IN PC12 CELLS
| العنوان: | EFFECT OF HYDROGEN SULPHIDE ON β‐AMYLOID‐INDUCED DAMAGE IN PC12 CELLS |
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| المؤلفون: | Tang, Xiao‐Qing, Yang, Chun‐Tao, Chen, Jing, Yin, Wei‐Lan, Tian, Shao‐Wen, Hu, Bi, Feng, Jian‐qiang, Li, Yuan‐Jian |
| المصدر: | Clinical and Experimental Pharmacology and Physiology ; volume 35, issue 2, page 180-186 ; ISSN 0305-1870 1440-1681 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2007 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | SUMMARY Hydrogen sulphide (H 2 S) is a well‐known cytotoxic gas. Recently, H 2 S has been shown to protect neurons against oxidative stress caused by glutamate, peroxynitrite and HOCl. Considerably lower H 2 S levels have been reported in the brain of Alzheimer's disease (AD) patients with accumulation of β‐amyloid (Aβ). The aim of present study was to explore the cytoprotection by H 2 S against Aβ 25–35 ‐induced apoptosis and the molecular mechanisms underlying this effect in PC12 cells. Our findings indicated that Aβ 25–35 significantly reduced cell viability and induced apoptosis of PC12 cells, along with dissipation of the mitochondrial membrane potential (MMP) and overproduction of reactive oxygen species (ROS). Sodium hydrosulphide (NaHS), an H 2 S donor, protected PC12 cells against Aβ 25–35 ‐induced cytotoxicity and apoptosis not only by reducing the loss of MMP, but also by attenuating the increase in intracellular ROS. The results of the present study suggest that the cytoprotection by H 2 S is related to the preservation of MMP and attenuation of Aβ 25–35 ‐induced intracellular ROS generation. These findings could significantly advance therapeutic approaches to the neurodegenerative diseases that are associated with oxidative stress, such as AD. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/j.1440-1681.2007.04799.x |
| الاتاحة: | http://dx.doi.org/10.1111/j.1440-1681.2007.04799.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1440-1681.2007.04799.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1440-1681.2007.04799.x |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.13FD8667 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/j.1440-1681.2007.04799.x |
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