Academic Journal
Advanced lung organoids and lung-on-a-chip for cancer research and drug evaluation: a review
| العنوان: | Advanced lung organoids and lung-on-a-chip for cancer research and drug evaluation: a review |
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| المؤلفون: | Zhu, Leqing, Zhang, Jianhua, Guo, Quanwei, Kuang, Jun, Li, Dongfang, Wu, Mengxi, Mo, Yijun, Zhang, Tao, Gao, Xinghua, Tan, Jianfeng |
| المصدر: | Frontiers in Bioengineering and Biotechnology ; volume 11 ; ISSN 2296-4185 |
| بيانات النشر: | Frontiers Media SA |
| سنة النشر: | 2023 |
| المجموعة: | Frontiers (Publisher - via CrossRef) |
| الوصف: | Lung cancer has become the primary cause of cancer-related deaths because of its high recurrence rate, ability to metastasise easily, and propensity to develop drug resistance. The wide-ranging heterogeneity of lung cancer subtypes increases the complexity of developing effective therapeutic interventions. Therefore, personalised diagnostic and treatment strategies are required to guide clinical practice. The advent of innovative three-dimensional (3D) culture systems such as organoid and organ-on-a-chip models provides opportunities to address these challenges and revolutionise lung cancer research and drug evaluation. In this review, we introduce the advancements in lung-related 3D culture systems, with a particular focus on lung organoids and lung-on-a-chip, and their latest contributions to lung cancer research and drug evaluation. These developments include various aspects, from authentic simulations and mechanistic enquiries into lung cancer to assessing chemotherapeutic agents and targeted therapeutic interventions. The new 3D culture system can mimic the pathological and physiological microenvironment of the lung, enabling it to supplement or replace existing two-dimensional culture models and animal experimental models and realize the potential for personalised lung cancer treatment. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.3389/fbioe.2023.1299033 |
| DOI: | 10.3389/fbioe.2023.1299033/full |
| الاتاحة: | http://dx.doi.org/10.3389/fbioe.2023.1299033 https://www.frontiersin.org/articles/10.3389/fbioe.2023.1299033/full |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.13E4926D |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fbioe.2023.1299033 |
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