Academic Journal
Developing Strategies to Block Beta-Catenin Action in Signaling and Cell Adhesion During Carcinogenesis
| العنوان: | Developing Strategies to Block Beta-Catenin Action in Signaling and Cell Adhesion During Carcinogenesis |
|---|---|
| المؤلفون: | Peifer, Mark |
| المساهمون: | NORTH CAROLINA UNIV AT CHAPEL HILL |
| المصدر: | DTIC |
| سنة النشر: | 2001 |
| المجموعة: | Defense Technical Information Center: DTIC Technical Reports database |
| مصطلحات موضوعية: | Biochemistry, Anatomy and Physiology, Medicine and Medical Research, BREAST CANCER, PROTEINS, ADHESION, MUTATIONS, MOLECULAR BIOLOGY, GENES, CELLS(BIOLOGY), ONCOGENESIS, BETA-CATENIN ACTION, WINGLESS (WG)/WNT SIGNALS, CELL ADHESION |
| الوصف: | To understand cancer, we must first understand normal cell behavior. Drosophila Armadillo (Arm) and its human homolog 13-catenin are key players in adhesive junctions and in transduction of Wingless (Wg)/Wnt signals. Our working hypotheses are: 1) Several protein partners compete to bind Arm, and 2) Arm:dTCF activates Wg-responsive genes, while dTCF alone represses the same genes. Aim 1 is to understand how different partners compete with one another for binding Arm. Aim 2 focuses on how Arm and dTCF positively and negatively regulate Wg-responsive genes. In the past year we made significant progress. We used the two-hybrid system to further define the Arm binding site on DE-cadherin and extended our analysis of the effect of point mutations on binding. Our collaborators at the Weizmann Institute completed a parallel analysis in mammalian cells, assessing the ability of cadherin-derived peptides to compete 13-catenin from its endogenous partners. This work was published in Molecular Biology of the Cell. We have also introduced into transgenic flies mutant versions of DE-cadherin which should specifically block Arm or pl20catenin binding. ; --Original contains color plates: All DTIC reproductions will be in black and white. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| Relation: | http://www.dtic.mil/docs/citations/ADA398037 |
| الاتاحة: | http://www.dtic.mil/docs/citations/ADA398037 http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA398037 |
| Rights: | APPROVED FOR PUBLIC RELEASE |
| رقم الانضمام: | edsbas.13D44D03 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |