التفاصيل البيبلوغرافية
| العنوان: |
Kidney Involvement in Systemic Sclerosis |
| المؤلفون: |
Francesco Reggiani, Gabriella Moroni, Claudio Ponticelli |
| المصدر: |
Journal of Personalized Medicine; Volume 12; Issue 7; Pages: 1123 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2022 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
systemic sclerosis, scleroderma renal crisis, kidney involvement |
| الوصف: |
Background: Systemic sclerosis is a chronic multisystem autoimmune disease, characterized by diffuse fibrosis and abnormalities of microcirculation and small arterioles in the skin, joints and visceral organs. Material and Methods: We searched for the relevant articles on systemic sclerosis and kidney involvement in systemic sclerosis in the NIH library of medicine, transplant, rheumatologic and nephrological journals. Results: Half of patients with systemic sclerosis have clinical evidence of kidney involvement. Scleroderma renal crisis represents the most specific and serious renal event associated with this condition. It is characterized by an abrupt onset of moderate to marked hypertension and kidney failure. Early and aggressive treatment is mandatory to prevent irreversible organ damage and death. The advent of ACE-inhibitors revolutionized the management of scleroderma renal crisis. However, the outcomes of this serious complication are still poor, and between 20 to 50% of patients progress to end stage renal disease. Conclusions: Scleroderma renal crisis still represents a serious and life-threatening event. Thus, further studies on its prevention and on new therapeutic strategies should be encouraged. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Clinical Medicine, Cell, and Organism Physiology; https://dx.doi.org/10.3390/jpm12071123 |
| DOI: |
10.3390/jpm12071123 |
| الاتاحة: |
https://doi.org/10.3390/jpm12071123 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.13D0EA4C |
| قاعدة البيانات: |
BASE |