Academic Journal
Resistance to Two Vinylglycine Antibiotic Analogs Is Conferred by Inactivation of Two Separate Amino Acid Transporters in Erwinia amylovora
| العنوان: | Resistance to Two Vinylglycine Antibiotic Analogs Is Conferred by Inactivation of Two Separate Amino Acid Transporters in Erwinia amylovora |
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| المؤلفون: | Smith, Derek D. N., Williams, Ashley N., Verrett, Jennifer N., Bergbusch, Nathanael T., Manning, Viola, Trippe, Kristin, Stavrinides, John |
| المساهمون: | Silhavy, Thomas J., USDA | Agricultural Research Service, Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada, Gouvernement du Canada | Canadian Institutes of Health Research, Canada Foundation for Innovation |
| المصدر: | Journal of Bacteriology ; volume 201, issue 9 ; ISSN 0021-9193 1098-5530 |
| بيانات النشر: | American Society for Microbiology |
| سنة النشر: | 2019 |
| الوصف: | The related antibiotics formylaminooxyvinylglycine (FVG) and aminoethoxyvinylglycine (AVG) have been shown to have activity against the fire blight pathogen Erwinia amylovora ; however, E. amylovora can develop spontaneous resistance to these antibiotics. By comparing the genomes of mutants to those of the wild type, we found that inactivation of the l -asparagine transporter conferred resistance to FVG, while inactivation of the l -arginine transporter conferred resistance to AVG. We also show that the transporter encoded by the FVG biosynthetic cluster can confer resistance to both FVG and AVG. Our work indicates the important role that amino acid transporters play in the import of antibiotics and highlights the possible utility in designer antibiotics that enter the bacterial cell through amino acid transporters. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1128/jb.00658-18 |
| DOI: | 10.1128/JB.00658-18 |
| الاتاحة: | http://dx.doi.org/10.1128/jb.00658-18 https://journals.asm.org/doi/pdf/10.1128/JB.00658-18 |
| Rights: | https://journals.asm.org/non-commercial-tdm-license |
| رقم الانضمام: | edsbas.13C8CCA5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1128/jb.00658-18 |
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