Academic Journal
Anti-GM-CSF Neutralizing Autoantibodies in Colombian Patients with Disseminated Cryptococcosis
| العنوان: | Anti-GM-CSF Neutralizing Autoantibodies in Colombian Patients with Disseminated Cryptococcosis |
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| المؤلفون: | Arango-Franco, Carlos A., Migaud, Mélanie, Ramírez-Sánchez, Isabel Cristina, Arango-Bustamante, Karen, Moncada-Vélez, Marcela, Rojas, Julián, Gervais, Adrian, Patiño-Giraldo, Santiago, Perez-Zapata, Lizeth J., Álvarez Álvarez, Jesús A., Orrego, Julio César, Roncancio-Villamil, Gustavo, Boisson-Dupuis, Stéphanie, Jouanguy, Emmanuelle, Abel, Laurent, Casanova, Jean-Laurent, Bustamante, Jacinta, Arias, Andrés A., Franco, José Luis, Puel, Anne |
| المساهمون: | Departamento Administrativo de Ciencia, Tecnología e Innovación, ECOS-NORD, Comité para el desarrollo de la investigación CODI UdeA, ESID European Society for Immunodeficiencies, Fundación “Diana-García de Olarte” para las Inmunodeficiencias Primarias (FIP, National Institutes of Health, NIH Clinical and Translational Science Award, French National Research Agency, Integrative Biology of Emerging Infectious Diseases Laboratory of Excellence, Cross Lab Imagine Grant, French Foundation for Medical Research |
| المصدر: | Journal of Clinical Immunology ; volume 43, issue 5, page 921-932 ; ISSN 0271-9142 1573-2592 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2023 |
| الوصف: | Background Cryptococcosis is a potentially life-threatening fungal disease caused by encapsulated yeasts of the genus Cryptococcus , mostly C. neoformans or C. gattii. Cryptococcal meningitis is the most frequent clinical manifestation in humans. Neutralizing autoantibodies (auto-Abs) against granulocyte–macrophage colony-stimulating factor (GM-CSF) have recently been discovered in otherwise healthy adult patients with cryptococcal meningitis, mostly caused by C. gattii . We hypothesized that three Colombian patients with cryptococcal meningitis caused by C. neoformans in two of them would carry high plasma levels of neutralizing auto-Abs against GM-CSF. Methods We reviewed medical and laboratory records, performed immunological evaluations, and tested for anti-cytokine auto-Abs three previously healthy HIV-negative adults with disseminated cryptococcosis. Results Peripheral blood leukocyte subset levels and serum immunoglobulin concentrations were within the normal ranges. We detected high levels of neutralizing auto-Abs against GM-CSF in the plasma of all three patients. Conclusions We report three Colombian patients with disseminated cryptococcosis associated with neutralizing auto-Abs against GM-CSF. Further studies should evaluate the genetic contribution to anti-GM-CSF autoantibody production and the role of the GM-CSF signaling pathway in the immune response to Cryptococcus spp. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1007/s10875-023-01451-5 |
| DOI: | 10.1007/s10875-023-01451-5.pdf |
| DOI: | 10.1007/s10875-023-01451-5/fulltext.html |
| الاتاحة: | http://dx.doi.org/10.1007/s10875-023-01451-5 https://link.springer.com/content/pdf/10.1007/s10875-023-01451-5.pdf https://link.springer.com/article/10.1007/s10875-023-01451-5/fulltext.html |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.13C70B38 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s10875-023-01451-5 |
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