Academic Journal
Dynorphins in Development and Disease: Implications for Cardiovascular Disease
| العنوان: | Dynorphins in Development and Disease: Implications for Cardiovascular Disease |
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| المؤلفون: | Cissom, Cody, J. Paris, Jason, Shariat-Madar, Zia |
| المساهمون: | National Institute on Drug Abuse |
| المصدر: | Current Molecular Medicine ; volume 20, issue 4, page 259-274 ; ISSN 1566-5240 |
| بيانات النشر: | Bentham Science Publishers Ltd. |
| سنة النشر: | 2020 |
| الوصف: | It is well-established that cardiovascular disease continues to represent a growing health problem and significant effort has been made to elucidate the underlying mechanisms. In this review, we report on past and recent high impact publications in the field of intracrine network signaling, focusing specifically on opioids and their interrelation with key modulators of the cardiovascular system and the onset of related disease. We present an overview of studies outlining the scope of cardiovascular and cerebrovascular processes that are affected by opioids, including heart function, ischemia, reperfusion, and blood flow. Specific emphasis is placed on the importance of dynorphin molecules in cerebrovascular and cardiovascular regulation. Evidence suggests that excessive or insufficient dynorphin could make an important contribution to cardiovascular physiology, yet numerous paradoxical observations frequently impede a clear understanding of the role of dynorphin. Thus, we argue that dynorphin-mediated signaling events for which an immediate regulatory effect is disputed should not be dismissed as unimportant, as they may play a role in cross-talk with other signaling networks. Finally, we consider the most recent evidence on the role of dynorphin during cardiovascular-related inflammation and on the potential value of endogenous and exogenous inhibitors of kappa-opioid receptor, a major dynorphin A receptor, to limit or prevent cardiovascular disease and its related sequelae. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.2174/1566524019666191028122559 |
| الاتاحة: | http://dx.doi.org/10.2174/1566524019666191028122559 http://eurekaselect.com/article/download/176244 |
| رقم الانضمام: | edsbas.13BA1E82 |
| قاعدة البيانات: | BASE |
| DOI: | 10.2174/1566524019666191028122559 |
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