Academic Journal
Hyperglycaemic clamp test for diabetes risk assessment in IA-2-antibody-positive relatives of type 1 diabetic patients
| العنوان: | Hyperglycaemic clamp test for diabetes risk assessment in IA-2-antibody-positive relatives of type 1 diabetic patients |
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| المؤلفون: | Vandemeulebroucke, E., Keymeulen, B., Decochez, K., Weets, I., De Block, C., Féry, F., Van de Velde, U., Vermeulen, I., De Pauw, P., Mathieu, C., Pipeleers, D. G., Paquot, Nicolas, Gorus, F. K. |
| المصدر: | Diabetologia, 53, 36-44 (2010-01) |
| بيانات النشر: | Springer Verlag |
| سنة النشر: | 2010 |
| المجموعة: | University of Liège: ORBi (Open Repository and Bibliography) |
| مصطلحات موضوعية: | Autoantibodies/*blood C-Peptide/blood, C-Peptide/blood MH - Diabetes Mellitus/*epidemiology/genetics MH - Diabetes Mellitus, Type 1/genetics/immunology MH - MH - Risk Assessment, Reference Values, Medical History Taking, Insulin/blood, Hyperglycemia, Humans, HLA-DQ Antigens/genetics, Glucose Clamp Technique, diabtes mellitus Type 1/genetics/immunology, Human health sciences, Endocrinology, metabolism & nutrition, Sciences de la santé humaine, Endocrinologie, métabolisme & nutrition |
| الوصف: | peer reviewed ; AIMS/HYPOTHESIS: The aim of the study was to investigate the use of hyperglycaemic clamp tests to identify individuals who will develop diabetes among insulinoma-associated protein-2 antibody (IA-2A)-positive first-degree relatives (IA-2A(+) FDRs) of type 1 diabetic patients. METHODS: Hyperglycaemic clamps were performed in 17 non-diabetic IA-2A(+) FDRs aged 14 to 33 years and in 21 matched healthy volunteers (HVs). Insulin and C-peptide responses were measured during the first (5-10 min) and second (120-150 min) release phase, and after glucagon injection (150-160 min). Clamp-induced C-peptide release was compared with C-peptide release during OGTT. RESULTS: Seven (41%) FDRs developed diabetes 3-63 months after their initial clamp test. In all phases they had lower C-peptide responses than non-progressors (p < 0.05) and HVs (p < 0.002). All five FDRs with low first-phase release also had low second-phase release and developed diabetes 3-21 months later. Two of seven FDRs with normal first-phase but low second-phase release developed diabetes after 34 and 63 months, respectively. None of the five FDRs with normal C-peptide responses in all test phases has developed diabetes so far (follow-up 56 to 99 months). OGTT-induced C-peptide release also tended to be lower in progressors than in non-progressors or HVs, but there was less overlap in results between progressors and the other groups using the clamp. CONCLUSIONS/INTERPRETATION: Clamp-derived functional variables stratify risk of diabetes in IA-2A(+) FDRs and may more consistently identify progressors than OGTT-derived variables. A low first-phase C-peptide response specifically predicts impending diabetes while a low second-phase response may reflect an earlier disease stage |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0012-186X 1432-0428 |
| Relation: | urn:issn:0012-186X; urn:issn:1432-0428; https://orbi.uliege.be/handle/2268/90903; info:hdl:2268/90903; https://orbi.uliege.be/bitstream/2268/90903/1/hyperglycaemic%20clamp%20ocr.pdf; info:pmid:19898832 |
| DOI: | 10.1007/s00125-009-1569-3 |
| الاتاحة: | https://orbi.uliege.be/handle/2268/90903 https://orbi.uliege.be/bitstream/2268/90903/1/hyperglycaemic%20clamp%20ocr.pdf https://doi.org/10.1007/s00125-009-1569-3 |
| Rights: | open access ; http://purl.org/coar/access_right/c_abf2 ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.139687B2 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 0012186X 14320428 |
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| DOI: | 10.1007/s00125-009-1569-3 |